Entity Details

Primary name MSH2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP43247
EntryNameMSH2_MOUSE
FullNameDNA mismatch repair protein Msh2
TaxID10090
Evidenceevidence at protein level
Length935
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMsh2

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000400 four-way junction DNA binding
GO:0000406 double-strand/single-strand DNA junction binding
GO:0001701 in utero embryonic development
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0006119 oxidative phosphorylation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006301 postreplication repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007281 germ cell development
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008340 determination of adult lifespan
GO:0008584 male gonad development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165 response to X-ray
GO:0010224 response to UV-B
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0016887 ATP hydrolysis activity
GO:0019237 centromeric DNA binding
GO:0019724 B cell mediated immunity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0030983 mismatched DNA binding
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0032137 guanine/thymine mispair binding
GO:0032142 single guanine insertion binding
GO:0032143 single thymine insertion binding
GO:0032181 dinucleotide repeat insertion binding
GO:0032300 mismatch repair complex
GO:0032301 MutSalpha complex
GO:0032302 MutSbeta complex
GO:0032357 oxidized purine DNA binding
GO:0032405 MutLalpha complex binding
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 protein homodimerization activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043531 ADP binding
GO:0043570 maintenance of DNA repeat elements
GO:0045190 isotype switching
GO:0045910 negative regulation of DNA recombination
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0051096 positive regulation of helicase activity
GO:0071168 protein localization to chromatin

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000432 DNA mismatch repair protein MutS, C-terminalDomainDomain
IPR007695 DNA mismatch repair protein MutS-like, N-terminalDomainDomain
IPR007696 DNA mismatch repair protein MutS, coreDomainDomain
IPR007860 DNA mismatch repair protein MutS, connector domainDomainDomain
IPR007861 DNA mismatch repair protein MutS, clampDomainDomain
IPR011184 DNA mismatch repair Msh2-typeFamilyFamily
IPR016151 DNA mismatch repair protein MutS, N-terminalFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032642 DNA mismatch repair protein Msh2FamilyFamily
IPR036187 DNA mismatch repair protein MutS, core domain superfamilyFamilyHomologous superfamily
IPR036678 MutS, connector domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions