Entity Details

Primary name TNFL4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP43488
EntryNameTNFL4_MOUSE
FullNameTumor necrosis factor ligand superfamily member 4
TaxID10090
Evidenceevidence at protein level
Length198
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesTnfsf4

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0002215 defense response to nematode
GO:0002526 acute inflammatory response
GO:0002639 positive regulation of immunoglobulin production
GO:0002699 positive regulation of immune effector process
GO:0002726 positive regulation of T cell cytokine production
GO:0002819 regulation of adaptive immune response
GO:0002830 positive regulation of type 2 immune response
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005615 extracellular space
GO:0006954 inflammatory response
GO:0008203 cholesterol metabolic process
GO:0009615 response to virus
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0035709 memory T cell activation
GO:0035712 T-helper 2 cell activation
GO:0035713 response to nitrogen dioxide
GO:0035714 cellular response to nitrogen dioxide
GO:0035783 CD4-positive, alpha-beta T cell costimulation
GO:0042098 T cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043382 positive regulation of memory T cell differentiation
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045087 innate immune response
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050871 positive regulation of B cell activation
GO:0070233 negative regulation of T cell apoptotic process
GO:0070236 negative regulation of activation-induced cell death of T cells
GO:0071222 cellular response to lipopolysaccharide
GO:0071380 cellular response to prostaglandin E stimulus
GO:1900281 positive regulation of CD4-positive, alpha-beta T cell costimulation
GO:2000406 positive regulation of T cell migration
GO:2000525 positive regulation of T cell costimulation
GO:2000568 positive regulation of memory T cell activation
GO:2000570 positive regulation of T-helper 2 cell activation
GO:2000572 positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR006052 Tumour necrosis factor domainDomainDomain
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site
IPR042338 Tumor necrosis factor ligand superfamily member 4FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TNFL4_MOUSETNFL4_HUMANDIP16905106 details
TNFL4_MOUSETNFL4_MOUSEDIP16905106 details