Entity Details

Primary name HOIL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BYM8
EntryNameHOIL1_HUMAN
FullNameRanBP-type and C3HC4-type zinc finger-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length510
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesRBCK1

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005829 cytosol
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046872 metal ion binding
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051220 cytoplasmic sequestering of protein
GO:0060546 negative regulation of necroptotic process
GO:0071797 LUBAC complex
GO:0097039 protein linear polyubiquitination
GO:0140311 protein sequestering activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000626 Ubiquitin-like domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001876 Zinc finger, RanBP2-typeDomainDomain
IPR002867 IBR domainDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR026261 RanBP-type and C3HC4-type zinc finger-containing protein 1/SHARPINFamilyFamily
IPR027370 RING-type zinc-finger, LisH dimerisation motifDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036443 Zinc finger, RanBP2-type superfamilyFamilyHomologous superfamily
IPR044066 TRIAD supradomainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
HOIL1_HUMANSOCS6_MOUSEBioGRID, MINT16643902 details
HOIL1_HUMANHXA1_MOUSEIntAct23088713 details