Entity Details

Primary name TRIM5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9C035
EntryNameTRIM5_HUMAN
FullNameTripartite motif-containing protein 5
TaxID9606
Evidenceevidence at protein level
Length493
SequenceStatuscomplete
DateCreated2003-11-28
DateModified2021-06-02

Ontological Relatives

GenesTRIM5

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000932 P-body
GO:0002218 activation of innate immune response
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006914 autophagy
GO:0008270 zinc ion binding
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0019901 protein kinase binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880 regulation of protein localization
GO:0038187 pattern recognition receptor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response
GO:0046596 regulation of viral entry into host cell
GO:0046597 negative regulation of viral entry into host cell
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0061630 ubiquitin protein ligase activity
GO:0070534 protein K63-linked ubiquitination
GO:1902187 negative regulation of viral release from host cell

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003877 SPRY domainDomainDomain
IPR003879 Butyrophylin-like, SPRY domainDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027370 RING-type zinc-finger, LisH dimerisation motifDomainDomain
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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