Entity Details

Primary name NEDD4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP46935
EntryNameNEDD4_MOUSE
FullNameE3 ubiquitin-protein ligase NEDD4
TaxID10090
Evidenceevidence at protein level
Length887
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNedd4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0002250 adaptive immune response
GO:0003151 outflow tract morphogenesis
GO:0003197 endocardial cushion development
GO:0004842 ubiquitin-protein transferase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0007528 neuromuscular junction development
GO:0008022 protein C-terminus binding
GO:0010766 negative regulation of sodium ion transport
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0019871 sodium channel inhibitor activity
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175 neuron projection development
GO:0031623 receptor internalization
GO:0032801 receptor catabolic process
GO:0035255 ionotropic glutamate receptor binding
GO:0042110 T cell activation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 dendritic spine
GO:0045121 membrane raft
GO:0045732 positive regulation of protein catabolic process
GO:0048514 blood vessel morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050807 regulation of synapse organization
GO:0050815 phosphoserine residue binding
GO:0050816 phosphothreonine residue binding
GO:0061630 ubiquitin protein ligase activity
GO:0070064 proline-rich region binding
GO:0070534 protein K63-linked ubiquitination
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:0099524 postsynaptic cytosol
GO:0099576 regulation of protein catabolic process at postsynapse, modulating synaptic transmission
GO:2000650 negative regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
NEDD4_MOUSEGRB10_MOUSEBioGRID, MINT10446181 20980250 details
NEDD4_MOUSEN4BP3_HUMANBioGRID, MINT11717310 details
NEDD4_MOUSEN4BP1_HUMANMINT11717310 details
NEDD4_MOUSEUB2D2_HUMANBioGRID, MINT16337426 9182527 details
NEDD4_MOUSEMED28_HUMANMINT16964398 details
NEDD4_MOUSELITAF_MOUSEBioGRID, IntAct11042109 details
NEDD4_MOUSEWBP1_MOUSEBioGRID, IntAct11042109 details
NEDD4_MOUSERNF11_MOUSEBioGRID, IntAct11042109 details
NEDD4_MOUSEBEAN1_MOUSEBioGRID, IntAct11042109 details
NEDD4_MOUSENFIP1_MOUSEBioGRID, IntAct11042109 11748237 22417925 details
NEDD4_MOUSETMG2_MOUSEBioGRID, IntAct11042109 details
NEDD4_MOUSEWBP2_MOUSEBioGRID, IntAct11042109 details
NEDD4_MOUSEPMEPA_MOUSEIntAct11042109 details
NEDD4_MOUSELAPM5_MOUSEBioGRID, DIP18562292 details
NEDD4_MOUSEUBP2_MOUSEBioGRID21478478 details
NEDD4_MOUSESCNNA_MOUSEBioGRID10212229 15123669 18687683 32325033 details
NEDD4_MOUSESCN5A_HUMANBioGRID15548568 details
NEDD4_MOUSESCN3A_HUMANBioGRID15548568 details
NEDD4_MOUSEARBK1_MOUSEBioGRID17544362 details
NEDD4_MOUSESCNNB_MOUSEBioGRID10212229 15123669 17544362 32325033 details
NEDD4_MOUSENFE2_HUMANBioGRID9305852 details
NEDD4_MOUSESCNNG_MOUSEBioGRID10212229 15123669 details
NEDD4_MOUSEHUNK_MOUSEBioGRID22745772 details
NEDD4_MOUSESCN1A_MOUSEBioGRID15123669 details
NEDD4_MOUSESCN2A_MOUSEBioGRID15123669 details
NEDD4_MOUSESCN3A_MOUSEBioGRID15123669 details
NEDD4_MOUSESCN5A_MOUSEBioGRID15123669 details
NEDD4_MOUSESCN8A_MOUSEBioGRID15123669 details
NEDD4_MOUSESCN9A_MOUSEBioGRID15123669 details
NEDD4_MOUSESCNAA_MOUSEBioGRID15123669 details
NEDD4_MOUSENMDE1_HUMANBioGRID23639431 details
NEDD4_MOUSEGUCD1_HUMANBioGRID24743017 details
NEDD4_MOUSENEDD4_MOUSEBioGRID11435423 details
NEDD4_MOUSEUB2D3_HUMANBioGRID11435423 details
NEDD4_MOUSEGLIS3_HUMANBioGRID26147758 details
NEDD4_MOUSELRAD3_HUMANBioGRID26854353 details
NEDD4_MOUSEN4BP1_MOUSEBioGRID16337426 details
NEDD4_MOUSEUB2D1_HUMANBioGRID16337426 details
NEDD4_MOUSEUB2L3_HUMANBioGRID16337426 details
NEDD4_MOUSEA4_MOUSEBioGRID27325702 details
NEDD4_MOUSE1433B_MOUSEBioGRID, IntAct16099816 16635246 18687683 details
NEDD4_MOUSETNIK_MOUSEBioGRID, IntAct20159449 28671696 details
NEDD4_MOUSERAP2A_MOUSEBioGRID20159449 details
NEDD4_MOUSE1433E_MOUSEBioGRID18687683 details
NEDD4_MOUSECBL_MOUSEBioGRID18931680 details
NEDD4_MOUSERPB1_HUMANBioGRID9305852 details
NEDD4_MOUSEDLG3_MOUSEBioGRID21920314 details
NEDD4_MOUSETRAF3_MOUSEBioGRID25072696 details
NEDD4_MOUSETNR5_MOUSEBioGRID25072696 details
NEDD4_MOUSETRAF2_MOUSEBioGRID25072696 details
NEDD4_MOUSEAICDA_MOUSEBioGRID23964096 details
NEDD4_MOUSEPPARG_MOUSEBioGRID27917940 details
NEDD4_MOUSEZBT7B_MOUSEBioGRID28784777 details