Entity Details

Primary name GRM8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP47743
EntryNameGRM8_MOUSE
FullNameMetabotropic glutamate receptor 8
TaxID10090
Evidenceevidence at protein level
Length908
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesGrm8

GO terms

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GOName
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0001642 group III metabotropic glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005887 integral component of plasma membrane
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008066 glutamate receptor activity
GO:0035249 synaptic transmission, glutamatergic
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0046928 regulation of neurotransmitter secretion
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099059 integral component of presynaptic active zone membrane
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000144 GPCR, family 3, metabotropic glutamate receptor 8FamilyFamily
IPR000162 GPCR, family 3, metabotropic glutamate receptorFamilyFamily
IPR000337 GPCR, family 3FamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR011500 GPCR, family 3, nine cysteines domainDomainDomain
IPR017978 GPCR family 3, C-terminalDomainDomain
IPR017979 GPCR, family 3, conserved siteSiteConserved site
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR038550 GPCR, family 3, nine cysteines domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
GRM8_MOUSERANB9_MOUSEMINT18555800 details