Entity Details

Primary name MK14_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP47811
EntryNameMK14_MOUSE
FullNameMitogen-activated protein kinase 14
TaxID10090
Evidenceevidence at protein level
Length360
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesMapk14

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000165 MAPK cascade
GO:0000902 cell morphogenesis
GO:0000922 spindle pole
GO:0001502 cartilage condensation
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0001890 placenta development
GO:0002062 chondrocyte differentiation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007519 skeletal muscle tissue development
GO:0008022 protein C-terminus binding
GO:0010628 positive regulation of gene expression
GO:0010831 positive regulation of myotube differentiation
GO:0014835 myoblast differentiation involved in skeletal muscle regeneration
GO:0016301 kinase activity
GO:0016607 nuclear speck
GO:0018105 peptidyl-serine phosphorylation
GO:0019395 fatty acid oxidation
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030278 regulation of ossification
GO:0030316 osteoclast differentiation
GO:0031281 positive regulation of cyclase activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0032735 positive regulation of interleukin-12 production
GO:0035331 negative regulation of hippo signaling
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0035994 response to muscle stretch
GO:0038066 p38MAPK cascade
GO:0042307 positive regulation of protein import into nucleus
GO:0042770 signal transduction in response to DNA damage
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of glucose import
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048273 mitogen-activated protein kinase p38 binding
GO:0051146 striated muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0051525 NFAT protein binding
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060348 bone development
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071356 cellular response to tumor necrosis factor
GO:0071479 cellular response to ionizing radiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090400 stress-induced premature senescence
GO:0098586 cellular response to virus
GO:0098978 glutamatergic synapse
GO:0099179 regulation of synaptic membrane adhesion
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1901741 positive regulation of myoblast fusion
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008352 Mitogen-activated protein (MAP) kinase p38-likeFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR038784 Mitogen-activated protein kinase 14FamilyFamily

Diseases

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Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
MK14_MOUSEATF2_MOUSEBioGRID, MINT15192015 15304344 15767678 details
MK14_MOUSEMK11_MOUSEIntAct15102471 details
MK14_MOUSEPLSL_MOUSEIntAct15102471 details
MK14_MOUSESP1_MOUSEIntAct15102471 details
MK14_MOUSEMK12_MOUSEIntAct15102471 details
MK14_MOUSEMK09_MOUSEIntAct15102471 details
MK14_MOUSEMIB1_MOUSEIntAct15102471 details
MK14_MOUSECCAR1_MOUSEIntAct15102471 details
MK14_MOUSEIL2RG_MOUSEIntAct15102471 details
MK14_MOUSENDKB_MOUSEIntAct15102471 details
MK14_MOUSERCN2_MOUSEIntAct15102471 details
MK14_MOUSECOPB_MOUSEIntAct15102471 details
MK14_MOUSEMAPK2_MOUSEBioGRID, MINT15538386 19369945 details
MK14_MOUSEDUS10_HUMANMINT16288922 details
MK14_MOUSEDUS2_MOUSEBioGRID, MINT16288922 details
MK14_MOUSEDUS9_HUMANMINT11988087 details
MK14_MOUSEMAPK2_HUMANBioGRID, DIP15287722 17395714 31505169 details
MK14_MOUSEGA45A_HUMANBioGRID12748288 details
MK14_MOUSESP20H_MOUSEBioGRID16751104 details
MK14_MOUSESP20H_HUMANBioGRID16751104 details
MK14_MOUSEMP2K3_MOUSEBioGRID15644321 details
MK14_MOUSEMP2K6_MOUSEBioGRID15644321 details
MK14_MOUSEJIP4_MOUSEBioGRID15767678 details
MK14_MOUSESHC1_MOUSEBioGRID16251354 details
MK14_MOUSEHSPB2_MOUSEBioGRID17015449 details
MK14_MOUSEDAB1_MOUSEBioGRID15110774 details
MK14_MOUSESTK39_MOUSEBioGRID, IntAct12386165 14563843 details
MK14_MOUSES12A2_MOUSEIntAct14563843 details
MK14_MOUSEP53_MOUSEBioGRID, MINT21050851 details
MK14_MOUSEP53_HUMANMINT21050851 details
MK14_MOUSEPTN7_HUMANMINT10415025 12583813 details
MK14_MOUSEPTPRR_MOUSEMINT12583813 details
MK14_MOUSEPRKN_MOUSEMINT29899409 details
MK14_MOUSEDUS4_HUMANBioGRID11062068 details
MK14_MOUSEMP2K6_HUMANBioGRID11062068 details
MK14_MOUSEMP2K3_HUMANBioGRID11062068 details
MK14_MOUSEEGFR_MOUSEBioGRID17139251 details
MK14_MOUSENBR1_MOUSEBioGRID20616007 details
MK14_MOUSECEBPB_MOUSEBioGRID21847090 details
MK14_MOUSEDLG1_MOUSEBioGRID17187070 details
MK14_MOUSEMAFA_HUMANBioGRID23660596 details
MK14_MOUSEAKT1_MOUSEBioGRID17015449 details
MK14_MOUSESRSF3_HUMANBioGRID31505169 details
MK14_MOUSESNW1_HUMANBioGRID31505169 details