Entity Details

Primary name SMUF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HAU4
EntryNameSMUF2_HUMAN
FullNameE3 ubiquitin-protein ligase SMURF2
TaxID9606
Evidenceevidence at protein level
Length748
SequenceStatuscomplete
DateCreated2001-12-13
DateModified2021-06-02

Ontological Relatives

GenesSMURF2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0016607 nuclear speck
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0042802 identical protein binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045121 membrane raft
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046332 SMAD binding
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061630 ubiquitin protein ligase activity
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901165 positive regulation of trophoblast cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane raft
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SMUF2_HUMANTOP2A_MOUSEBioGRID28611047 details