Entity Details

Primary name SOX2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP48432
EntryNameSOX2_MOUSE
FullNameTranscription factor SOX-2
TaxID10090
Evidenceevidence at protein level
Length319
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesSox2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001649 osteoblast differentiation
GO:0001708 cell fate specification
GO:0001714 endodermal cell fate specification
GO:0002052 positive regulation of neuroblast proliferation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007605 sensory perception of sound
GO:0008134 transcription factor binding
GO:0009653 anatomical structure morphogenesis
GO:0010033 response to organic substance
GO:0010468 regulation of gene expression
GO:0019827 stem cell population maintenance
GO:0021879 forebrain neuron differentiation
GO:0021984 adenohypophysis development
GO:0021987 cerebral cortex development
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030539 male genitalia development
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030910 olfactory placode formation
GO:0031490 chromatin DNA binding
GO:0032526 response to retinoic acid
GO:0035019 somatic stem cell population maintenance
GO:0035198 miRNA binding
GO:0042472 inner ear morphogenesis
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043565 sequence-specific DNA binding
GO:0043586 tongue development
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046148 pigment biosynthetic process
GO:0048286 lung alveolus development
GO:0048568 embryonic organ development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048663 neuron fate commitment
GO:0048839 inner ear development
GO:0048852 diencephalon morphogenesis
GO:0048863 stem cell differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0050973 detection of mechanical stimulus involved in equilibrioception
GO:0060042 retina morphogenesis in camera-type eye
GO:0060235 lens induction in camera-type eye
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0070848 response to growth factor
GO:0071276 cellular response to cadmium ion
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell population maintenance

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR022097 Transcription factor SOXFamilyFamily
IPR032643 Transcription factor SOX-2FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
SOX2_MOUSEHDAC1_MOUSEBioGRID, IntAct19139101 21103394 21321941 31077711 details
SOX2_MOUSEPO5F1_MOUSEBioGRID, IntAct, MINT15863505 17507372 20362541 21962512 22036565 22344693 23108051 31077711 details
SOX2_MOUSETYY1_MOUSEBioGRID, DIP19536159 31077711 details
SOX2_MOUSEPAX6_MOUSEBioGRID, IntAct20211142 details
SOX2_MOUSEALX4_MOUSEBioGRID, IntAct20211142 details
SOX2_MOUSEERG_MOUSEBioGRID, IntAct20211142 details
SOX2_MOUSEXPO4_MOUSEBioGRID19349578 details
SOX2_MOUSEUBC9_MOUSEBioGRID17097055 details
SOX2_MOUSESALL4_MOUSEBioGRID21103394 23269686 31077711 details
SOX2_MOUSESIX1_MOUSEBioGRID22340499 22513373 details
SOX2_MOUSEEYA1_MOUSEBioGRID22340499 22513373 details
SOX2_MOUSEAKT1_MOUSEBioGRID25042802 details
SOX2_MOUSESTF1_MOUSEBioGRID12732652 details
SOX2_MOUSEERR2_MOUSEBioGRID23169531 31077711 details
SOX2_MOUSECBX1_MOUSEBioGRID31077711 details
SOX2_MOUSECBX5_MOUSEBioGRID31077711 details
SOX2_MOUSEHDAC2_MOUSEBioGRID, IntAct19139101 21103394 details
SOX2_MOUSESIN3A_MOUSEBioGRID, IntAct19139101 31077711 details
SOX2_MOUSENANOG_MOUSEBioGRID, IntAct, MINT18454139 21589869 21962512 23892456 31077711 details
SOX2_MOUSECTNB1_MOUSEBioGRID15781477 details
SOX2_MOUSELN28A_MOUSEBioGRID21103394 details
SOX2_MOUSESOX2_MOUSEBioGRID17507372 21103394 details
SOX2_MOUSERAD21_MOUSEBioGRID21589869 details
SOX2_MOUSEWWP2_MOUSEBioGRID25042802 details
SOX2_MOUSEOGT1_MOUSEBioGRID22608532 31077711 details
SOX2_MOUSELMBL3_MOUSEBioGRID30442713 details
SOX2_MOUSERCOR2_MOUSEBioGRID30442713 details
SOX2_MOUSECUL4A_MOUSEBioGRID30442713 details
SOX2_MOUSECUL4B_MOUSEBioGRID30442713 details
SOX2_MOUSEDDB1_MOUSEBioGRID30442713 details
SOX2_MOUSEDCAF5_MOUSEBioGRID30442713 details