Entity Details

Primary name LMNA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP48678
EntryNameLMNA_MOUSE
FullNamePrelamin-A/C
TaxID10090
Evidenceevidence at protein level
Length665
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesLmna

GO terms

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GOName
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005638 lamin filament
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006606 protein import into nucleus
GO:0006997 nucleus organization
GO:0006998 nuclear envelope organization
GO:0007517 muscle organ development
GO:0008157 protein phosphatase 1 binding
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0030010 establishment of cell polarity
GO:0030334 regulation of cell migration
GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity
GO:0031647 regulation of protein stability
GO:0031965 nuclear membrane
GO:0032204 regulation of telomere maintenance
GO:0034504 protein localization to nucleus
GO:0034613 cellular protein localization
GO:0035861 site of double-strand break
GO:0042802 identical protein binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0055015 ventricular cardiac muscle cell development
GO:0071456 cellular response to hypoxia
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090343 positive regulation of cell aging
GO:1900114 positive regulation of histone H3-K9 trimethylation
GO:1900180 regulation of protein localization to nucleus
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
GO:1904178 negative regulation of adipose tissue development
GO:1990683 DNA double-strand break attachment to nuclear envelope
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus
Nucleus envelope
Nucleus lamina
Nucleus matrix

Domains

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DomainNameCategoryType
IPR001322 Lamin tail domainDomainDomain
IPR018039 Intermediate filament protein, conserved siteSiteConserved site
IPR036415 Lamin tail domain superfamilyFamilyHomologous superfamily
IPR039008 Intermediate filament, rod domainDomainDomain

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
LMNA_MOUSEAKT1_MOUSEDIP, MINT18388859 23686339 details
LMNA_MOUSEMLIP_MOUSEBioGRID, UniProt21498514 details
LMNA_MOUSEH2AX_MOUSEIntAct23658700 details
LMNA_MOUSETM201_MOUSEUniProt22349700 details
LMNA_MOUSESUN2_MOUSEBioGRID, UniProt16380439 21327095 22349700 details
LMNA_MOUSELMNB1_MOUSEBioGRID21327095 details
LMNA_MOUSELMNB2_MOUSEBioGRID21327095 details
LMNA_MOUSEHNRH2_MOUSEBioGRID21327095 details
LMNA_MOUSEDX39B_MOUSEBioGRID21327095 details
LMNA_MOUSELBR_MOUSEBioGRID21327095 details
LMNA_MOUSETOIP1_MOUSEBioGRID21327095 details
LMNA_MOUSESUN1_MOUSEBioGRID16380439 21327095 details
LMNA_MOUSEHNRL1_MOUSEBioGRID21327095 details
LMNA_MOUSEMYH9_MOUSEBioGRID21327095 details
LMNA_MOUSE1433G_MOUSEBioGRID21327095 details
LMNA_MOUSERAB5A_MOUSEBioGRID21327095 details
LMNA_MOUSEEMD_MOUSEBioGRID21327095 32325033 details
LMNA_MOUSEDDX3Y_MOUSEBioGRID21327095 details
LMNA_MOUSERBM10_MOUSEBioGRID21327095 details
LMNA_MOUSE1433S_MOUSEBioGRID21327095 details
LMNA_MOUSERED_MOUSEBioGRID21327095 details
LMNA_MOUSEUBC9_MOUSEBioGRID21327095 details
LMNA_MOUSEPPIL1_MOUSEBioGRID21327095 details
LMNA_MOUSETOP2A_MOUSEBioGRID21327095 details
LMNA_MOUSERAB2A_MOUSEBioGRID21327095 details
LMNA_MOUSEENPL_MOUSEBioGRID21327095 details
LMNA_MOUSEMAN1_MOUSEBioGRID21327095 details
LMNA_MOUSETNPO1_MOUSEBioGRID21327095 details
LMNA_MOUSESYNE2_MOUSEBioGRID21327095 details
LMNA_MOUSERAB5C_MOUSEBioGRID21327095 details
LMNA_MOUSEACTG_MOUSEBioGRID21327095 details
LMNA_MOUSERAB7A_MOUSEBioGRID21327095 details
LMNA_MOUSEH14_MOUSEBioGRID21327095 details
LMNA_MOUSEANXA3_MOUSEBioGRID21327095 details
LMNA_MOUSEEIF3I_MOUSEBioGRID21327095 details
LMNA_MOUSERAB10_MOUSEBioGRID21327095 details
LMNA_MOUSELUC7L_MOUSEBioGRID21327095 details
LMNA_MOUSECBX5_MOUSEBioGRID21327095 details
LMNA_MOUSEARC1B_MOUSEBioGRID21327095 details
LMNA_MOUSERAB6B_MOUSEBioGRID21327095 details
LMNA_MOUSEPIPNB_MOUSEBioGRID21327095 details
LMNA_MOUSETIF1B_MOUSEBioGRID21327095 details
LMNA_MOUSESC22B_MOUSEBioGRID21327095 details
LMNA_MOUSEPAIRB_MOUSEBioGRID21327095 details
LMNA_MOUSESTRAP_MOUSEBioGRID21327095 details
LMNA_MOUSEMTAP_MOUSEBioGRID21327095 details
LMNA_MOUSELAR4B_MOUSEBioGRID21327095 details
LMNA_MOUSECNN3_MOUSEBioGRID21327095 details
LMNA_MOUSEPSB5_MOUSEBioGRID21327095 details
LMNA_MOUSEGT251_MOUSEBioGRID21327095 details
LMNA_MOUSEESTD_MOUSEBioGRID21327095 details
LMNA_MOUSEXRCC6_MOUSEBioGRID21327095 details