Entity Details

Primary name TF7L2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQB0
EntryNameTF7L2_HUMAN
FullNameTranscription factor 7-like 2
TaxID9606
Evidenceevidence at protein level
Length619
SequenceStatuscomplete
DateCreated2003-03-25
DateModified2021-06-02

Ontological Relatives

GenesTCF7L2

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0009749 response to glucose
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0016605 PML body
GO:0019901 protein kinase binding
GO:0031016 pancreas development
GO:0032024 positive regulation of insulin secretion
GO:0032092 positive regulation of protein binding
GO:0032350 regulation of hormone metabolic process
GO:0032993 protein-DNA complex
GO:0042593 glucose homeostasis
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0043570 maintenance of DNA repeat elements
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045295 gamma-catenin binding
GO:0045444 fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046827 positive regulation of protein export from nucleus
GO:0048625 myoblast fate commitment
GO:0048660 regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070016 armadillo repeat domain binding
GO:0070369 beta-catenin-TCF7L2 complex
GO:0071664 catenin-TCF7L2 complex
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1904837 beta-catenin-TCF complex assembly
GO:1990907 beta-catenin-TCF complex
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR013558 CTNNB1 binding, N-teminalDomainDomain
IPR024940 Transcription factor TCF/LEFFamilyFamily
IPR027397 Catenin binding domain superfamilyFamilyHomologous superfamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TF7L2_HUMANCTNB1_MOUSEBioGRID, IntAct12417018 22014570 details