Entity Details

Primary name LOX5_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP48999
EntryNameLOX5_MOUSE
FullNamePolyunsaturated fatty acid 5-lipoxygenase
TaxID10090
Evidenceevidence at protein level
Length674
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesAlox5

GO terms

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GOName
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002526 acute inflammatory response
GO:0002540 leukotriene production involved in inflammatory response
GO:0004051 arachidonate 5-lipoxygenase activity
GO:0004052 arachidonate 12(S)-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005641 nuclear envelope lumen
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006691 leukotriene metabolic process
GO:0006954 inflammatory response
GO:0006959 humoral immune response
GO:0016363 nuclear matrix
GO:0016525 negative regulation of angiogenesis
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016787 hydrolase activity
GO:0019233 sensory perception of pain
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019372 lipoxygenase pathway
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0031965 nuclear membrane
GO:0034440 lipid oxidation
GO:0036336 dendritic cell migration
GO:0036403 arachidonate 8(S)-lipoxygenase activity
GO:0042383 sarcolemma
GO:0042593 glucose homeostasis
GO:0043651 linoleic acid metabolic process
GO:0045598 regulation of fat cell differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050796 regulation of insulin secretion
GO:0051122 hepoxilin biosynthetic process
GO:0061044 negative regulation of vascular wound healing
GO:0061045 negative regulation of wound healing
GO:0106014 regulation of inflammatory response to wounding
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900407 regulation of cellular response to oxidative stress
GO:1901753 leukotriene A4 biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1903671 negative regulation of sprouting angiogenesis
GO:1904960 positive regulation of cytochrome-c oxidase activity
GO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell
GO:2001301 lipoxin biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus envelope
Nucleus intermembrane space
Nucleus matrix
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000907 LipoxygenaseFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR001885 Lipoxygenase, mammalianFamilyFamily
IPR013819 Lipoxygenase, C-terminalDomainDomain
IPR020833 Lipoxygenase, iron binding siteSiteBinding site
IPR020834 Lipoxygenase, conserved siteSiteConserved site
IPR036226 Lipoxigenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily
IPR042062 Lipoxygenase, vertebrates, PLAT domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LOX5_MOUSEAL5AP_MOUSEBioGRID19075240 details
LOX5_MOUSEGSAP_MOUSEBioGRID26076991 details