Entity Details

Primary name TOPRS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NS56
EntryNameTOPRS_HUMAN
FullNameE3 ubiquitin-protein ligase Topors
TaxID9606
Evidenceevidence at protein level
Length1045
SequenceStatuscomplete
DateCreated2006-04-18
DateModified2021-06-02

Ontological Relatives

GenesTOPORS

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0000922 spindle pole
GO:0000930 gamma-tubulin complex
GO:0003677 DNA binding
GO:0003823 antigen binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005814 centriole
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010842 retina layer formation
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0016925 protein sumoylation
GO:0019789 SUMO transferase activity
GO:0030496 midbody
GO:0032391 photoreceptor connecting cilium
GO:0034504 protein localization to nucleus
GO:0035845 photoreceptor cell outer segment organization
GO:0036064 ciliary basal body
GO:0042127 regulation of cell population proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044547 DNA topoisomerase binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046548 retinal rod cell development
GO:0046549 retinal cone cell development
GO:0046872 metal ion binding
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051457 maintenance of protein location in nucleus
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TOPRS_HUMANP53_MOUSEBioGRID, UniProt10415337 11842245 details