Entity Details

Primary name RAD18_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NS91
EntryNameRAD18_HUMAN
FullNameE3 ubiquitin-protein ligase RAD18
TaxID9606
Evidenceevidence at protein level
Length495
SequenceStatuscomplete
DateCreated2002-06-06
DateModified2021-06-02

Ontological Relatives

GenesRAD18

GO terms

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GOName
GO:0000403 Y-form DNA binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006281 DNA repair
GO:0006301 postreplication repair
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0016604 nuclear body
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0035861 site of double-strand break
GO:0042405 nuclear inclusion body
GO:0042769 DNA damage response, detection of DNA damage
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0051865 protein autoubiquitination
GO:0051984 positive regulation of chromosome segregation
GO:0060548 negative regulation of cell death
GO:0061630 ubiquitin protein ligase activity
GO:0097505 Rad6-Rad18 complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR003034 SAP domainDomainDomain
IPR006642 Rad18, zinc finger UBZ4-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR036361 SAP domain superfamilyFamilyHomologous superfamily
IPR039577 E3 ubiquitin-protein ligase Rad18FamilyFamily

Diseases

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Interactions

3 interactions