Entity Details

Primary name HNF4A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP49698
EntryNameHNF4A_MOUSE
FullNameHepatocyte nuclear factor 4-alpha
TaxID10090
Evidenceevidence at protein level
Length474
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesHnf4a

GO terms

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GOName
GO:0000062 fatty-acyl-CoA binding
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003323 type B pancreatic cell development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005102 signaling receptor binding
GO:0005504 fatty acid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006591 ornithine metabolic process
GO:0006629 lipid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007164 establishment of tissue polarity
GO:0007548 sex differentiation
GO:0007596 blood coagulation
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009749 response to glucose
GO:0010470 regulation of gastrulation
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0019216 regulation of lipid metabolic process
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0032534 regulation of microvillus assembly
GO:0036042 long-chain fatty acyl-CoA binding
GO:0042308 negative regulation of protein import into nucleus
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0044877 protein-containing complex binding
GO:0045216 cell-cell junction organization
GO:0045722 positive regulation of gluconeogenesis
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0048856 anatomical structure development
GO:0050544 arachidonic acid binding
GO:0050796 regulation of insulin secretion
GO:0055088 lipid homeostasis
GO:0055091 phospholipid homeostasis
GO:0060395 SMAD protein signal transduction
GO:0070328 triglyceride homeostasis
GO:0070365 hepatocyte differentiation
GO:0070540 stearic acid binding
GO:1902569 negative regulation of activation of Janus kinase activity
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR039067 Hepatocyte nuclear factor 4-alphaFamilyFamily

Diseases

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