Entity Details

Primary name HIF1N_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NWT6
EntryNameHIF1N_HUMAN
FullNameHypoxia-inducible factor 1-alpha inhibitor
TaxID9606
Evidenceevidence at protein level
Length349
SequenceStatuscomplete
DateCreated2003-06-16
DateModified2021-06-02

Ontological Relatives

GenesHIF1AN

GO terms

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GOName
GO:0005112 Notch binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0019826 oxygen sensor activity
GO:0031406 carboxylic acid binding
GO:0036138 peptidyl-histidine hydroxylation
GO:0036139 peptidyl-histidine dioxygenase activity
GO:0036140 peptidyl-asparagine 3-dioxygenase activity
GO:0042264 peptidyl-aspartic acid hydroxylation
GO:0042265 peptidyl-asparagine hydroxylation
GO:0042803 protein homodimerization activity
GO:0045663 positive regulation of myoblast differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051059 NF-kappaB binding
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071532 ankyrin repeat binding
GO:0102113 hypoxia-inducible factor-asparagine oxygenase activity
GO:2001214 positive regulation of vasculogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003347 JmjC domainDomainDomain
IPR027445 Hypoxia-inducible factor 1-alpha inhibitorFamilyFamily
IPR027452 Hypoxia-inducible factor 1-alpha inhibitor, domain IIFamilyHomologous superfamily
IPR041667 Cupin-like domain 8DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01694 D-tartaric acidDrugbanksmall molecule
DB08263 N-(carboxycarbonyl)-D-phenylalanineDrugbanksmall molecule
DB09459 L-tartaric acidSwissprotsmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HIF1N_HUMANMIB1_MOUSEBioGRID25347788 details