Entity Details

Primary name IRAK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NWZ3
EntryNameIRAK4_HUMAN
FullNameInterleukin-1 receptor-associated kinase 4
TaxID9606
Evidenceevidence at protein level
Length460
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesIRAK4

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0002224 toll-like receptor signaling pathway
GO:0002446 neutrophil mediated immunity
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0005149 interleukin-1 receptor binding
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007254 JNK cascade
GO:0010008 endosome membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0035556 intracellular signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0070498 interleukin-1-mediated signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990266 neutrophil migration

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017428 Interleukin-1 receptor-associated kinase 4FamilyFamily
IPR037970 IRAK4, Death domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB08590 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
IRAK4_HUMANIRAK3_MOUSEMINT23376919 details