Entity Details

Primary name ARHGC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NZN5
EntryNameARHGC_HUMAN
FullNameRho guanine nucleotide exchange factor 12
TaxID9606
Evidenceevidence at protein level
Length1544
SequenceStatuscomplete
DateCreated2003-08-29
DateModified2021-06-02

Ontological Relatives

GenesARHGEF12

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007266 Rho protein signal transduction
GO:0016020 membrane
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001478 PDZ domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015212 Regulator of G protein signalling-like domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR037801 ARHGEF12, PH domainDomainDomain
IPR037884 LARG, RGS domainDomainDomain
IPR041020 ARHGEF1-like, PH domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ARHGC_HUMANLPAR1_MOUSEMINT15755723 details
ARHGC_HUMANLPAR2_MOUSEMINT15755723 details