Entity Details

Primary name DNM3B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBC3
EntryNameDNM3B_HUMAN
FullNameDNA (cytosine-5)-methyltransferase 3B
TaxID9606
Evidenceevidence at protein level
Length853
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesDNMT3B

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001666 response to hypoxia
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006306 DNA methylation
GO:0009008 DNA-methyltransferase activity
GO:0009636 response to toxic substance
GO:0010212 response to ionizing radiation
GO:0010628 positive regulation of gene expression
GO:0014823 response to activity
GO:0031000 response to caffeine
GO:0032355 response to estradiol
GO:0033189 response to vitamin A
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042826 histone deacetylase binding
GO:0045666 positive regulation of neuron differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0046872 metal ion binding
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0071455 cellular response to hyperoxia
GO:0071549 cellular response to dexamethasone stimulus

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000313 PWWP domainDomainDomain
IPR001525 C-5 cytosine methyltransferaseFamilyFamily
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR018117 DNA methylase, C-5 cytosine-specific, active siteSiteActive site
IPR025766 ADD domainDomainDomain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR030488 DNA (cytosine-5)-methyltransferase 3B, ADD domainDomainDomain
IPR040552 DNMT3, cysteine rich ADD domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01262 DecitabineDrugbanksmall molecule

Interactions

0 interactions

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