Entity Details

Primary name CNOT7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UIV1
EntryNameCNOT7_HUMAN
FullNameCCR4-NOT transcription complex subunit 7
TaxID9606
Evidenceevidence at protein level
Length285
SequenceStatuscomplete
DateCreated2001-08-14
DateModified2021-06-02

Ontological Relatives

GenesCNOT7

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 P-body
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0004532 exoribonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0017148 negative regulation of translation
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0031047 gene silencing by RNA
GO:0033962 P-body assembly
GO:0035195 gene silencing by miRNA
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0045070 positive regulation of viral genome replication
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0051607 defense response to virus
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061014 positive regulation of mRNA catabolic process
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR006941 Ribonuclease CAF1FamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR039636 CCR4-NOT transcription complex subunit 7FamilyFamily
IPR039637 CCR4-NOT transcription complex subunit 7/8/Pop2FamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CNOT7_HUMANTTP_MOUSEBioGRID, UniProt20595389 21278420 details