Entity Details

Primary name AGO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UL18
EntryNameAGO1_HUMAN
FullNameProtein argonaute-1
TaxID9606
Evidenceevidence at protein level
Length857
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesAGO1

GO terms

Show/Hide Table
GOName
GO:0000932 P-body
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0010501 RNA secondary structure unwinding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016442 RISC complex
GO:0016525 negative regulation of angiogenesis
GO:0030522 intracellular receptor signaling pathway
GO:0031054 pre-miRNA processing
GO:0035194 post-transcriptional gene silencing by RNA
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035198 miRNA binding
GO:0035278 miRNA mediated inhibition of translation
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0045652 regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060964 regulation of gene silencing by miRNA
GO:0070578 RISC-loading complex
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1990904 ribonucleoprotein complex

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR003100 PAZ domainDomainDomain
IPR003165 Piwi domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014811 Argonaute, linker 1 domainDomainDomain
IPR032472 Argonaute linker 2 domainDomainDomain
IPR032473 Protein argonaute, Mid domainDomainDomain
IPR032474 Protein argonaute, N-terminalDomainDomain
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AGO1_HUMANTRI32_MOUSEIntAct19269368 details