Entity Details

Primary name NOTC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UM47
EntryNameNOTC3_HUMAN
FullNameNeurogenic locus notch homolog protein 3
TaxID9606
Evidenceevidence at protein level
Length2321
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesNOTCH3

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007411 axon guidance
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016021 integral component of membrane
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045296 cadherin binding
GO:0045746 negative regulation of Notch signaling pathway
GO:0050793 regulation of developmental process

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000800 Notch domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008297 NotchFamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010660 Notch, NOD domainDomainDomain
IPR011656 Notch, NODP domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR022331 Neurogenic locus Notch 3FamilyFamily
IPR024600 Domain of unknown function DUF3454, notchDomainDomain
IPR035993 Notch-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
NOTC3_HUMANPSA1_MOUSEIntAct17292860 details