Entity Details

Primary name SUFU_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UMX1
EntryNameSUFU_HUMAN
FullNameSuppressor of fused homolog
TaxID9606
Evidenceevidence at protein level
Length484
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesSUFU

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001501 skeletal system development
GO:0001843 neural tube closure
GO:0001947 heart looping
GO:0003281 ventricular septum development
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006508 proteolysis
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0035904 aorta development
GO:0042308 negative regulation of protein import into nucleus
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043588 skin development
GO:0045668 negative regulation of osteoblast differentiation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0060976 coronary vasculature development
GO:0097542 ciliary tip
GO:0097546 ciliary base
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR007768 Suppressor of fusedFamilyFamily
IPR016591 Suppressor of fused, eukaryoticFamilyFamily
IPR020941 Suppressor of fused-like domainDomainDomain
IPR024314 Suppressor of fused C-terminalDomainDomain
IPR037181 Suppressor of fused, N-terminalFamilyHomologous superfamily
IPR038489 Suppressor of fused, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions