Entity Details

Primary name CHIP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UNE7
EntryNameCHIP_HUMAN
FullNameE3 ubiquitin-protein ligase CHIP
TaxID9606
Evidenceevidence at protein level
Length303
SequenceStatuscomplete
DateCreated2005-10-25
DateModified2021-06-02

Ontological Relatives

GenesSTUB1

GO terms

Show/Hide Table
GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0001664 G protein-coupled receptor binding
GO:0002931 response to ischemia
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0016567 protein ubiquitination
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0030018 Z disc
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030544 Hsp70 protein binding
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0030674 protein-macromolecule adaptor activity
GO:0030911 TPR domain binding
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031072 heat shock protein binding
GO:0031371 ubiquitin conjugating enzyme complex
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031943 regulation of glucocorticoid metabolic process
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0034605 cellular response to heat
GO:0038128 ERBB2 signaling pathway
GO:0042405 nuclear inclusion body
GO:0042803 protein homodimerization activity
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045862 positive regulation of proteolysis
GO:0046332 SMAD binding
GO:0048156 tau protein binding
GO:0051087 chaperone binding
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051604 protein maturation
GO:0051787 misfolded protein binding
GO:0051865 protein autoubiquitination
GO:0051879 Hsp90 protein binding
GO:0060544 regulation of necroptotic process
GO:0061630 ubiquitin protein ligase activity
GO:0061684 chaperone-mediated autophagy
GO:0070534 protein K63-linked ubiquitination
GO:0071218 cellular response to misfolded protein
GO:0071456 cellular response to hypoxia
GO:0090035 positive regulation of chaperone-mediated protein complex assembly
GO:0101031 chaperone complex

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR003613 U box domainDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR041312 CHIP, N-terminal tetratricopeptide repeat domainDomainDomain

Diseases

Show/Hide Table