Entity Details

Primary name DICER_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UPY3
EntryNameDICER_HUMAN
FullNameEndoribonuclease Dicer
TaxID9606
Evidenceevidence at protein level
Length1922
SequenceStatuscomplete
DateCreated2002-10-25
DateModified2021-06-02

Ontological Relatives

GenesDICER1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004521 endoribonuclease activity
GO:0004525 ribonuclease III activity
GO:0004530 deoxyribonuclease I activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0006309 apoptotic DNA fragmentation
GO:0010586 miRNA metabolic process
GO:0010626 negative regulation of Schwann cell proliferation
GO:0010629 negative regulation of gene expression
GO:0014040 positive regulation of Schwann cell differentiation
GO:0016032 viral process
GO:0016442 RISC complex
GO:0019904 protein domain specific binding
GO:0021675 nerve development
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031054 pre-miRNA processing
GO:0031643 positive regulation of myelination
GO:0032290 peripheral nervous system myelin formation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033167 ARC complex
GO:0033168 conversion of ds siRNA to ss siRNA involved in RNA interference
GO:0035087 siRNA loading onto RISC involved in RNA interference
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035197 siRNA binding
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036404 conversion of ds siRNA to ss siRNA
GO:0038061 NIK/NF-kappaB signaling
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0048812 neuron projection morphogenesis
GO:0070062 extracellular exosome
GO:0070578 RISC-loading complex
GO:0070883 pre-miRNA binding
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000999 Ribonuclease III domainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR003100 PAZ domainDomainDomain
IPR005034 Dicer dimerisation domainDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036389 Ribonuclease III, endonuclease domain superfamilyFamilyHomologous superfamily
IPR038248 Dicer dimerisation domain superfamilyFamilyHomologous superfamily
IPR044441 Dicer, double-stranded RNA-binding domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DICER_HUMANDDX4_MOUSEDIP16477042 details
DICER_HUMANAGO2_MOUSEBioGRID, UniProt12526743 details