Entity Details

Primary name JIP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQF2
EntryNameJIP1_HUMAN
FullNameC-Jun-amino-terminal kinase-interacting protein 1
TaxID9606
Evidenceevidence at protein level
Length711
SequenceStatuscomplete
DateCreated2001-12-05
DateModified2021-06-02

Ontological Relatives

GenesMAPK8IP1

GO terms

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GOName
GO:0004860 protein kinase inhibitor activity
GO:0005078 MAP-kinase scaffold activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0007258 JUN phosphorylation
GO:0008432 JUN kinase binding
GO:0016192 vesicle-mediated transport
GO:0019894 kinesin binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031966 mitochondrial membrane
GO:0043508 negative regulation of JUN kinase activity
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0044297 cell body
GO:0044302 dentate gyrus mossy fiber
GO:0045202 synapse
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0048471 perinuclear region of cytoplasm
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Mitochondrion membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR006020 PTB/PI domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR035638 JIP1, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01782 PyrazolanthroneDrugbanksmall molecule
DB07218 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONEDrugbanksmall molecule
DB07272 N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDEDrugbanksmall molecule
DB07276 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDEDrugbanksmall molecule
DB11157 AnthralinDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
JIP1_HUMANA4_MOUSEMINT11517249 details
JIP1_HUMANJIP3_MOUSEMINT21750526 details