Entity Details

Primary name HDAC5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQL6
EntryNameHDAC5_HUMAN
FullNameHistone deacetylase 5
TaxID9606
Evidenceevidence at protein level
Length1122
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesHDAC5

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0004407 histone deacetylase activity
GO:0005080 protein kinase C binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006342 chromatin silencing
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006476 protein deacetylation
GO:0006954 inflammatory response
GO:0008134 transcription factor binding
GO:0010830 regulation of myotube differentiation
GO:0010832 negative regulation of myotube differentiation
GO:0014823 response to activity
GO:0016575 histone deacetylation
GO:0016607 nuclear speck
GO:0030182 neuron differentiation
GO:0030183 B cell differentiation
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032869 cellular response to insulin stimulus
GO:0033558 protein deacetylase activity
GO:0040029 regulation of gene expression, epigenetic
GO:0042113 B cell activation
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043393 regulation of protein binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0071222 cellular response to lipopolysaccharide
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR017320 Histone deacetylase class II, eukaryoticFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR024643 Histone deacetylase, glutamine rich N-terminal domainDomainDomain
IPR030703 Histone deacetylase 5FamilyFamily
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05015 BelinostatDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule