Entity Details

Primary name KCC2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQM7
EntryNameKCC2A_HUMAN
FullNameCalcium/calmodulin-dependent protein kinase type II subunit alpha
TaxID9606
Evidenceevidence at protein level
Length478
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesCAMK2A

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000165 MAPK cascade
GO:0002931 response to ischemia
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005954 calcium- and calmodulin-dependent protein kinase complex
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0014069 postsynaptic density
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0030666 endocytic vesicle membrane
GO:0035254 glutamate receptor binding
GO:0038166 angiotensin-activated signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0046928 regulation of neurotransmitter secretion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051346 negative regulation of hydrolase activity
GO:0051928 positive regulation of calcium ion transport
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060996 dendritic spine development
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1990443 peptidyl-threonine autophosphorylation
GO:2000124 regulation of endocannabinoid signaling pathway
GO:2000310 regulation of NMDA receptor activity
GO:2001222 regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR032710 NTF2-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04119 Hexatantalum DodecabromideDrugbanksmall molecule
DB04447 1,4-DithiothreitolDrugbanksmall molecule
DB07766 (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
KCC2A_HUMANCD5R2_MOUSEMINT12223541 details
KCC2A_HUMANOSTM1_MOUSEBioGRID26598607 details