Entity Details

Primary name HPSE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y251
EntryNameHPSE_HUMAN
FullNameHeparanase
TaxID9606
Evidenceevidence at protein level
Length543
SequenceStatuscomplete
DateCreated2005-10-11
DateModified2021-06-02

Ontological Relatives

GenesHPSE

GO terms

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GOName
GO:0004566 beta-glucuronidase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0006027 glycosaminoglycan catabolic process
GO:0006029 proteoglycan metabolic process
GO:0007160 cell-matrix adhesion
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0030194 positive regulation of blood coagulation
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0030305 heparanase activity
GO:0031012 extracellular matrix
GO:0033690 positive regulation of osteoblast proliferation
GO:0035580 specific granule lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0045121 membrane raft
GO:0045545 syndecan binding
GO:0051797 regulation of hair follicle development
GO:0051798 positive regulation of hair follicle development
GO:0051897 positive regulation of protein kinase B signaling
GO:0060055 angiogenesis involved in wound healing
GO:0061042 vascular wound healing
GO:1904974 heparanase complex

Subcellular Location

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Subcellular Location
Lysosome membrane
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR005199 Glycoside hydrolase, family 79FamilyFamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01109 HeparinDrugbanksmall molecule
DB06779 DalteparinDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink