Entity Details

Primary name AXIN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2T1
EntryNameAXIN2_HUMAN
FullNameAxin-2
TaxID9606
Evidenceevidence at protein level
Length843
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesAXIN2

GO terms

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GOName
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001957 intramembranous ossification
GO:0003139 secondary heart field specification
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0008013 beta-catenin binding
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010942 positive regulation of cell death
GO:0016055 Wnt signaling pathway
GO:0019899 enzyme binding
GO:0030282 bone mineralization
GO:0030877 beta-catenin destruction complex
GO:0031625 ubiquitin protein ligase binding
GO:0032423 regulation of mismatch repair
GO:0034613 cellular protein localization
GO:0042476 odontogenesis
GO:0043570 maintenance of DNA repeat elements
GO:0045668 negative regulation of osteoblast differentiation
GO:0048255 mRNA stabilization
GO:0061181 regulation of chondrocyte development
GO:0070411 I-SMAD binding
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1904837 beta-catenin-TCF complex assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001158 DIX domainDomainDomain
IPR014936 Axin beta-catenin bindingDomainDomain
IPR016137 RGS domainDomainDomain
IPR024066 RGS, subdomain 1/3FamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR032101 Axin-1/2, tankyrase-binding domainDomainDomain
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily
IPR043581 Axin-likeFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AXIN2_HUMANPLK1_MOUSEDIP16815967 details