Entity Details

Primary name STAT6_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP52633
EntryNameSTAT6_MOUSE
FullNameSignal transducer and transcription activator 6
TaxID10090
Evidenceevidence at protein level
Length837
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesStat6

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002296 T-helper 1 cell lineage commitment
GO:0002829 negative regulation of type 2 immune response
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006952 defense response
GO:0007165 signal transduction
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0033598 mammary gland epithelial cell proliferation
GO:0034097 response to cytokine
GO:0035771 interleukin-4-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0043434 response to peptide hormone
GO:0043565 sequence-specific DNA binding
GO:0045121 membrane raft
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0060443 mammary gland morphogenesis
GO:0070301 cellular response to hydrogen peroxide
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1902170 cellular response to reactive nitrogen species

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR028187 STAT6, C-terminalDomainDomain
IPR035857 STAT6, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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