Entity Details

Primary name HXK4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP52792
EntryNameHXK4_MOUSE
FullNameHexokinase-4
TaxID10090
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesGck

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001678 cellular glucose homeostasis
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005524 ATP binding
GO:0005536 glucose binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0005978 glycogen biosynthetic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006013 mannose metabolic process
GO:0006096 glycolytic process
GO:0006739 NADP metabolic process
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008865 fructokinase activity
GO:0019158 mannokinase activity
GO:0019903 protein phosphatase binding
GO:0019932 second-messenger-mediated signaling
GO:0030141 secretory granule
GO:0032024 positive regulation of insulin secretion
GO:0032811 negative regulation of epinephrine secretion
GO:0032869 cellular response to insulin stimulus
GO:0042149 cellular response to glucose starvation
GO:0042327 positive regulation of phosphorylation
GO:0042593 glucose homeostasis
GO:0043266 regulation of potassium ion transport
GO:0043531 ADP binding
GO:0044320 cellular response to leptin stimulus
GO:0045180 basal cortex
GO:0045721 negative regulation of gluconeogenesis
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0046835 carbohydrate phosphorylation
GO:0050796 regulation of insulin secretion
GO:0051156 glucose 6-phosphate metabolic process
GO:0051594 detection of glucose
GO:0055088 lipid homeostasis
GO:0070509 calcium ion import

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001312 HexokinaseFamilyFamily
IPR019807 Hexokinase, binding siteSiteBinding site
IPR022672 Hexokinase, N-terminalDomainDomain
IPR022673 Hexokinase, C-terminalDomainDomain
IPR039073 Hexokinase-4, chordateFamilyFamily
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Interactions

4 interactions