Entity Details

Primary name TRAF6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y4K3
EntryNameTRAF6_HUMAN
FullNameTNF receptor-associated factor 6
TaxID9606
Evidenceevidence at protein level
Length522
SequenceStatuscomplete
DateCreated2003-05-09
DateModified2021-06-02

Ontological Relatives

GenesTRAF6

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000187 obsolete activation of MAPK activity
GO:0000209 protein polyubiquitination
GO:0001503 ossification
GO:0001701 in utero embryonic development
GO:0001843 neural tube closure
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002637 regulation of immunoglobulin production
GO:0002726 positive regulation of T cell cytokine production
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006974 cellular response to DNA damage stimulus
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007254 JNK cascade
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0010008 endosome membrane
GO:0016579 protein deubiquitination
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0030316 osteoclast differentiation
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031398 positive regulation of protein ubiquitination
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0031996 thioesterase binding
GO:0032147 activation of protein kinase activity
GO:0032735 positive regulation of interleukin-12 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0035631 CD40 receptor complex
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042088 T-helper 1 type immune response
GO:0042102 positive regulation of T cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043011 myeloid dendritic cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043422 protein kinase B binding
GO:0043507 positive regulation of JUN kinase activity
GO:0045453 bone resorption
GO:0045672 positive regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0047485 protein N-terminus binding
GO:0048468 cell development
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070534 protein K63-linked ubiquitination
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071345 cellular response to cytokine stimulus
GO:0097400 interleukin-17-mediated signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:2000679 positive regulation of transcription regulatory region DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Lipid droplet
Nucleus

Domains

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DomainNameCategoryType
IPR001293 Zinc finger, TRAF-typeDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR002083 MATH/TRAF domainDomainDomain
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR012227 TNF receptor-associated factor TRAF, metazoaFamilyFamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027139 TNF receptor-associated factor 6FamilyFamily
IPR037309 TNF receptor-associated factor 6, MATH domainDomainDomain
IPR041310 TNF receptor-associated factor 6, zinc finger 2DomainDomain
IPR043211 TNF receptor-associated factor TRAFFamilyFamily

Diseases

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