Entity Details

Primary name NEMO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y6K9
EntryNameNEMO_HUMAN
FullNameNF-kappa-B essential modulator
TaxID9606
Evidenceevidence at protein level
Length419
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesIKBKG

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000187 obsolete activation of MAPK activity
GO:0000922 spindle pole
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0008385 IkappaB kinase complex
GO:0009615 response to virus
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0016579 protein deubiquitination
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0032991 protein-containing complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043276 anoikis
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051650 establishment of vesicle localization
GO:0065003 protein-containing complex assembly
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0072686 mitotic spindle
GO:1901215 negative regulation of neuron death
GO:1990450 linear polyubiquitin binding
GO:1990459 transferrin receptor binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR021063 NF-kappa-B essential modulator NEMO, N-terminalDomainDomain
IPR032419 NF-kappa-B essential modulator NEMO, CC2-LZ domainDomainDomain
IPR034735 NEMO, Zinc fingerDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04998 AGRO100Drugbanksmall molecule
DB05289 TarenflurbilDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
NEMO_HUMANIKKB_MOUSEBioGRID24266532 details