Entity Details

Primary name S12A1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP55014
EntryNameS12A1_MOUSE
FullNameSolute carrier family 12 member 1
TaxID10090
Evidenceevidence at protein level
Length1095
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesSlc12a1

GO terms

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GOName
GO:0001822 kidney development
GO:0005886 plasma membrane
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006821 chloride transport
GO:0006884 cell volume homeostasis
GO:0007588 excretion
GO:0008511 sodium:potassium:chloride symporter activity
GO:0009986 cell surface
GO:0015379 potassium:chloride symporter activity
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0032978 protein insertion into membrane from inner side
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0048878 chemical homeostasis
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0070062 extracellular exosome
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0071475 cellular hyperosmotic salinity response
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR002443 Solute carrier family 12 member 1/2FamilyFamily
IPR002445 Solute carrier family 12 member 1FamilyFamily
IPR004841 Amino acid permease/ SLC12A domainDomainDomain
IPR004842 SLC12A transporter familyFamilyFamily
IPR013612 Amino acid permease, N-terminalDomainDomain
IPR018491 SLC12A transporter, C-terminalDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
S12A1_MOUSEALDOB_HUMANIntAct17848580 details
S12A1_MOUSEOS9_HUMANBioGRID26721884 details