Entity Details

Primary name KMT2A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP55200
EntryNameKMT2A_MOUSE
FullNameHistone-lysine N-methyltransferase 2A
TaxID10090
Evidenceevidence at protein level
Length3966
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GO terms

Show/Hide Table
GOName
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006306 DNA methylation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008542 visual learning
GO:0009416 response to light stimulus
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0010468 regulation of gene expression
GO:0018026 peptidyl-lysine monomethylation
GO:0032411 positive regulation of transporter activity
GO:0032922 circadian regulation of gene expression
GO:0035097 histone methyltransferase complex
GO:0035162 embryonic hemopoiesis
GO:0035640 exploration behavior
GO:0035864 response to potassium ion
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043984 histone H4-K16 acetylation
GO:0044648 histone H3-K4 dimethylation
GO:0045322 unmethylated CpG binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0048536 spleen development
GO:0048873 homeostasis of number of cells within a tissue
GO:0050890 cognition
GO:0051568 histone H3-K4 methylation
GO:0051569 regulation of histone H3-K4 methylation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051899 membrane depolarization
GO:0060216 definitive hemopoiesis
GO:0065003 protein-containing complex assembly
GO:0070577 lysine-acetylated histone binding
GO:0071339 MLL1 complex
GO:0071440 regulation of histone H3-K14 acetylation
GO:0080182 histone H3-K4 trimethylation
GO:0097692 histone H3-K4 monomethylation
GO:0106363 protein-cysteine methyltransferase activity
GO:1901674 regulation of histone H3-K27 acetylation
GO:1905642 negative regulation of DNA methylation
GO:2000615 regulation of histone H3-K9 acetylation

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001487 BromodomainDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002857 Zinc finger, CXXC-typeDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR003888 FY-rich, N-terminalDomainDomain
IPR003889 FY-rich, C-terminalDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR016569 Methyltransferase, trithoraxFamilyFamily
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR034732 Extended PHD (ePHD) domainDomainDomain
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR037927 Histone-lysine N-methyltransferase 2AFamilyFamily
IPR041958 KMT2A, ePHD domainDomainDomain
IPR042023 KMT2A, PHD domain 1DomainDomain
IPR042025 KMT2A, PHD domain 2DomainDomain
IPR044133 KMT2A, PHD domain 3DomainDomain

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
KMT2A_MOUSESIR1_MOUSEDIP25751424 details