Entity Details

Primary name SMO_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP56726
EntryNameSMO_MOUSE
FullNameSmoothened homolog
TaxID10090
Evidenceevidence at protein level
Length793
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSmo

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001503 ossification
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001755 neural crest cell migration
GO:0001947 heart looping
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003007 heart morphogenesis
GO:0003140 determination of left/right asymmetry in lateral mesoderm
GO:0003323 type B pancreatic cell development
GO:0004930 G protein-coupled receptor activity
GO:0005113 patched binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005929 cilium
GO:0007224 smoothened signaling pathway
GO:0007228 positive regulation of hh target transcription factor activity
GO:0007368 determination of left/right symmetry
GO:0007371 ventral midline determination
GO:0007389 pattern specification process
GO:0007417 central nervous system development
GO:0007494 midgut development
GO:0008284 positive regulation of cell population proliferation
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0021542 dentate gyrus development
GO:0021696 cerebellar cortex morphogenesis
GO:0021794 thalamus development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953 central nervous system neuron differentiation
GO:0021987 cerebral cortex development
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0034504 protein localization to nucleus
GO:0035264 multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042307 positive regulation of protein import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046622 positive regulation of organ growth
GO:0048143 astrocyte activation
GO:0048468 cell development
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048589 developmental growth
GO:0048741 skeletal muscle fiber development
GO:0048745 smooth muscle tissue development
GO:0048846 axon extension involved in axon guidance
GO:0048853 forebrain morphogenesis
GO:0048873 homeostasis of number of cells within a tissue
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050821 protein stabilization
GO:0051451 myoblast migration
GO:0051799 negative regulation of hair follicle development
GO:0060170 ciliary membrane
GO:0060242 contact inhibition
GO:0060413 atrial septum morphogenesis
GO:0060644 mammary gland epithelial cell differentiation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0061053 somite development
GO:0061113 pancreas morphogenesis
GO:0070986 left/right axis specification
GO:0071397 cellular response to cholesterol
GO:0071679 commissural neuron axon guidance
GO:0072285 mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0097731 9+0 non-motile cilium
GO:1901215 negative regulation of neuron death
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:2000036 regulation of stem cell population maintenance
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000826 regulation of heart morphogenesis

Subcellular Location

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Subcellular Location
Cell projection
Membrane

Domains

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DomainNameCategoryType
IPR000539 Frizzled/Smoothened, transmembrane domainDomainDomain
IPR015526 Frizzled/secreted frizzled-related proteinFamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR026544 SmoothenedFamilyFamily
IPR035683 Smoothened, transmembrane domainDomainDomain
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041771 Smoothened, cysteine-rich domainDomainDomain

Diseases

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