Entity Details

Primary name BACE1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP56818
EntryNameBACE1_MOUSE
FullNameBeta-secretase 1
TaxID10090
Evidenceevidence at protein level
Length501
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesBace1

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007613 memory
GO:0008021 synaptic vesicle
GO:0008233 peptidase activity
GO:0009314 response to radiation
GO:0009986 cell surface
GO:0010288 response to lead ion
GO:0016020 membrane
GO:0016485 protein processing
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0034205 amyloid-beta formation
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 neuronal cell body
GO:0043525 positive regulation of neuron apoptotic process
GO:0045121 membrane raft
GO:0048167 regulation of synaptic plasticity
GO:0050435 amyloid-beta metabolic process
GO:0050804 modulation of chemical synaptic transmission
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0055037 recycling endosome
GO:0060134 prepulse inhibition
GO:0071280 cellular response to copper ion
GO:0071287 cellular response to manganese ion
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098793 presynapse
GO:1904646 cellular response to amyloid-beta
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cell surface
Cytoplasmic vesicle membrane
Early endosome
Endoplasmic reticulum
Endosome
Golgi apparatus
Late endosome
Lysosome
Membrane raft
Recycling endosome

Domains

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DomainNameCategoryType
IPR001461 Aspartic peptidase A1 familyFamilyFamily
IPR001969 Aspartic peptidase, active siteSiteActive site
IPR009119 Beta-secretase BACEFamilyFamily
IPR009120 Beta-secretase BACE1FamilyFamily
IPR021109 Aspartic peptidase domain superfamilyFamilyHomologous superfamily
IPR033121 Peptidase family A1 domainDomainDomain
IPR033874 Memapsin-likeDomainDomain

Diseases

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