Entity Details

Primary name NICA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP57716
EntryNameNICA_MOUSE
FullNameNicastrin
TaxID10090
Evidenceevidence at protein level
Length708
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesNcstn

GO terms

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GOName
GO:0002262 myeloid cell homeostasis
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006509 membrane protein ectodomain proteolysis
GO:0007212 dopamine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0007611 learning or memory
GO:0008021 synaptic vesicle
GO:0008233 peptidase activity
GO:0010950 positive regulation of endopeptidase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0021549 cerebellum development
GO:0022010 central nervous system myelination
GO:0030534 adult behavior
GO:0030659 cytoplasmic vesicle membrane
GO:0030674 protein-macromolecule adaptor activity
GO:0032991 protein-containing complex
GO:0034205 amyloid-beta formation
GO:0042098 T cell proliferation
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042982 amyloid precursor protein metabolic process
GO:0042983 amyloid precursor protein biosynthetic process
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043085 positive regulation of catalytic activity
GO:0045202 synapse
GO:0050435 amyloid-beta metabolic process
GO:0050673 epithelial cell proliferation
GO:0051117 ATPase binding
GO:0051402 neuron apoptotic process
GO:0070765 gamma-secretase complex
GO:0070851 growth factor receptor binding
GO:0070997 neuron death
GO:0071277 cellular response to calcium ion
GO:0097060 synaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:1900271 regulation of long-term synaptic potentiation
GO:1990926 short-term synaptic potentiation

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle membrane
Melanosome
Membrane

Domains

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DomainNameCategoryType
IPR008710 NicastrinFamilyFamily
IPR041084 Nicastrin, small lobeDomainDomain

Diseases

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