Entity Details

Primary name RIPK2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP58801
EntryNameRIPK2_MOUSE
FullNameReceptor-interacting serine/threonine-protein kinase 2
TaxID10090
Evidenceevidence at protein level
Length539
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesRipk2

GO terms

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GOName
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002250 adaptive immune response
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0004672 protein kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006915 apoptotic process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007257 obsolete activation of JUN kinase activity
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010942 positive regulation of cell death
GO:0030274 LIM domain binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031982 vesicle
GO:0032092 positive regulation of protein binding
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032991 protein-containing complex
GO:0033091 positive regulation of immature T cell proliferation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042098 T cell proliferation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0046330 positive regulation of JNK cascade
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050700 CARD domain binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050830 defense response to Gram-positive bacterium
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070555 response to interleukin-1
GO:0070671 response to interleukin-12
GO:0070673 response to interleukin-18
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0089720 caspase binding
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904417 positive regulation of xenophagy

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017322 Receptor-interacting serine/threonine-protein kinase 2FamilyFamily
IPR042149 RIP2, CARD domainDomainDomain

Diseases

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Interactions

4 interactions