Entity Details

Primary name SCN2A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionB1AWN6
EntryNameSCN2A_MOUSE
FullNameSodium channel protein type 2 subunit alpha
TaxID10090
Evidenceevidence at protein level
Length2006
SequenceStatuscomplete
DateCreated2019-04-10
DateModified2021-06-02

Ontological Relatives

GenesScn2a

GO terms

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GOName
GO:0001518 voltage-gated sodium channel complex
GO:0005248 voltage-gated sodium channel activity
GO:0005886 plasma membrane
GO:0006814 sodium ion transport
GO:0007399 nervous system development
GO:0007613 memory
GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0019228 neuronal action potential
GO:0030315 T-tubule
GO:0030424 axon
GO:0031226 intrinsic component of plasma membrane
GO:0031402 sodium ion binding
GO:0033268 node of Ranvier
GO:0033270 paranode region of axon
GO:0034706 sodium channel complex
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0043005 neuron projection
GO:0043194 axon initial segment
GO:0043522 leucine zipper domain binding
GO:0051402 neuron apoptotic process
GO:0071456 cellular response to hypoxia
GO:0086010 membrane depolarization during action potential
GO:0098978 glutamatergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099508 voltage-gated ion channel activity involved in regulation of presynaptic membrane potential

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR001696 Voltage gated sodium channel, alpha subunitFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR010526 Sodium ion transport-associatedDomainDomain
IPR024583 Voltage-gated Na+ ion channel, cytoplasmic domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR043203 Voltage-gated cation channel calcium and sodiumFamilyFamily
IPR044564 Voltage-gated sodium channel alpha subunit, inactivation gateDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SCN2A_MOUSENEDD4_MOUSEBioGRID15123669 details
SCN2A_MOUSEMYH9_MOUSEBioGRID29956586 details