Entity Details

Primary name SIR6_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP59941
EntryNameSIR6_MOUSE
FullNameNAD-dependent protein deacetylase sirtuin-6
TaxID10090
Evidenceevidence at protein level
Length334
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSirt6

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003247 post-embryonic cardiac muscle cell growth involved in heart morphogenesis
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006284 base-excision repair
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019213 deacetylase activity
GO:0031648 protein destabilization
GO:0031667 response to nutrient levels
GO:0031940 positive regulation of chromatin silencing at telomere
GO:0032206 positive regulation of telomere maintenance
GO:0033558 protein deacetylase activity
GO:0042593 glucose homeostasis
GO:0045820 negative regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046325 negative regulation of glucose import
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0048146 positive regulation of fibroblast proliferation
GO:0070403 NAD+ binding
GO:0070932 histone H3 deacetylation
GO:0099115 chromosome, subtelomeric region
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901485 positive regulation of transcription factor catabolic process
GO:1902732 positive regulation of chondrocyte proliferation
GO:1905549 positive regulation of subtelomeric heterochromatin assembly
GO:1905555 positive regulation of blood vessel branching
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000648 positive regulation of stem cell proliferation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions