Entity Details

Primary name DRD2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP61168
EntryNameDRD2_MOUSE
FullNameD(2) dopamine receptor
TaxID10090
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesDrd2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001659 temperature homeostasis
GO:0001666 response to hypoxia
GO:0001669 acrosomal vesicle
GO:0001933 negative regulation of protein phosphorylation
GO:0001964 startle response
GO:0001975 response to amphetamine
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure
GO:0002027 regulation of heart rate
GO:0002028 regulation of sodium ion transport
GO:0002031 G protein-coupled receptor internalization
GO:0002052 positive regulation of neuroblast proliferation
GO:0002092 positive regulation of receptor internalization
GO:0004930 G protein-coupled receptor activity
GO:0004952 dopamine neurotransmitter receptor activity
GO:0005102 signaling receptor binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006914 autophagy
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007270 neuron-neuron synaptic transmission
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0007608 sensory perception of smell
GO:0007616 long-term memory
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0007631 feeding behavior
GO:0008104 protein localization
GO:0008285 negative regulation of cell population proliferation
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009416 response to light stimulus
GO:0009636 response to toxic substance
GO:0010039 response to iron ion
GO:0014059 regulation of dopamine secretion
GO:0014069 postsynaptic density
GO:0014854 response to inactivity
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016328 lateral plasma membrane
GO:0021756 striatum development
GO:0021769 orbitofrontal cortex development
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0021984 adenohypophysis development
GO:0030139 endocytic vesicle
GO:0030336 negative regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030432 peristalsis
GO:0030534 adult behavior
GO:0030672 synaptic vesicle membrane
GO:0030900 forebrain development
GO:0031223 auditory behavior
GO:0031410 cytoplasmic vesicle
GO:0032147 activation of protein kinase activity
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032467 positive regulation of cytokinesis
GO:0032922 circadian regulation of gene expression
GO:0033602 negative regulation of dopamine secretion
GO:0034776 response to histamine
GO:0035094 response to nicotine
GO:0035240 dopamine binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035556 intracellular signal transduction
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0036126 sperm flagellum
GO:0040018 positive regulation of multicellular organism growth
GO:0042220 response to cocaine
GO:0042321 negative regulation of circadian sleep/wake cycle, sleep
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0042756 drinking behavior
GO:0042802 identical protein binding
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043266 regulation of potassium ion transport
GO:0043278 response to morphine
GO:0043408 regulation of MAPK cascade
GO:0043473 pigmentation
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0043679 axon terminus
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045776 negative regulation of blood pressure
GO:0045824 negative regulation of innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046676 negative regulation of insulin secretion
GO:0046717 acid secretion
GO:0048148 behavioral response to cocaine
GO:0048149 behavioral response to ethanol
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048678 response to axon injury
GO:0048755 branching morphogenesis of a nerve
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0050769 positive regulation of neurogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051580 regulation of neurotransmitter uptake
GO:0051584 regulation of dopamine uptake involved in synaptic transmission
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission
GO:0051823 regulation of synapse structural plasticity
GO:0051898 negative regulation of protein kinase B signaling
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060124 positive regulation of growth hormone secretion
GO:0060134 prepulse inhibition
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060160 negative regulation of dopamine receptor signaling pathway
GO:0060170 ciliary membrane
GO:0060548 negative regulation of cell death
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090325 regulation of locomotion involved in locomotory behavior
GO:0097730 non-motile cilium
GO:0098691 dopaminergic synapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:1900168 positive regulation of glial cell-derived neurotrophic factor production
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:1990384 hyaloid vascular plexus regression
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000929 Dopamine receptor familyFamilyFamily
IPR001922 Dopamine D2 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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