Entity Details

Primary name RAC1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP63001
EntryNameRAC1_MOUSE
FullNameRas-related C3 botulinum toxin substrate 1
TaxID10090
Evidenceevidence at protein level
Length192
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesRac1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000242 pericentriolar material
GO:0001764 neuron migration
GO:0001891 phagocytic cup
GO:0001934 positive regulation of protein phosphorylation
GO:0002093 auditory receptor cell morphogenesis
GO:0002551 mast cell chemotaxis
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0003382 epithelial cell morphogenesis
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006897 endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006935 chemotaxis
GO:0006972 hyperosmotic response
GO:0007010 cytoskeleton organization
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0008045 motor neuron axon guidance
GO:0008283 cell population proliferation
GO:0008360 regulation of cell shape
GO:0008361 regulation of cell size
GO:0010591 regulation of lamellipodium assembly
GO:0010592 positive regulation of lamellipodium assembly
GO:0010595 positive regulation of endothelial cell migration
GO:0010762 regulation of fibroblast migration
GO:0010764 negative regulation of fibroblast migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014041 regulation of neuron maturation
GO:0016020 membrane
GO:0016358 dendrite development
GO:0016477 cell migration
GO:0016601 Rac protein signal transduction
GO:0019897 extrinsic component of plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021831 embryonic olfactory bulb interneuron precursor migration
GO:0021894 cerebral cortex GABAergic interneuron development
GO:0022604 regulation of cell morphogenesis
GO:0030027 lamellipodium
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0030334 regulation of cell migration
GO:0030742 GTP-dependent protein binding
GO:0030838 positive regulation of actin filament polymerization
GO:0030865 cortical cytoskeleton organization
GO:0030900 forebrain development
GO:0031116 positive regulation of microtubule polymerization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031267 small GTPase binding
GO:0031410 cytoplasmic vesicle
GO:0031529 ruffle organization
GO:0031901 early endosome membrane
GO:0031996 thioesterase binding
GO:0032587 ruffle membrane
GO:0032707 negative regulation of interleukin-23 production
GO:0032956 regulation of actin cytoskeleton organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035567 non-canonical Wnt signaling pathway
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042470 melanosome
GO:0042826 histone deacetylase binding
GO:0042995 cell projection
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043652 engulfment of apoptotic cell
GO:0044877 protein-containing complex binding
GO:0045216 cell-cell junction organization
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045453 bone resorption
GO:0045740 positive regulation of DNA replication
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048532 anatomical structure arrangement
GO:0048812 neuron projection morphogenesis
GO:0048813 dendrite morphogenesis
GO:0048870 cell motility
GO:0048873 homeostasis of number of cells within a tissue
GO:0051022 Rho GDP-dissociation inhibitor binding
GO:0051117 ATPase binding
GO:0051492 regulation of stress fiber assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051668 localization within membrane
GO:0051894 positive regulation of focal adhesion assembly
GO:0051932 synaptic transmission, GABAergic
GO:0055038 recycling endosome membrane
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060091 kinocilium
GO:0060263 regulation of respiratory burst
GO:0060999 positive regulation of dendritic spine development
GO:0061344 regulation of cell adhesion involved in heart morphogenesis
GO:0071260 cellular response to mechanical stimulus
GO:0071526 semaphorin-plexin signaling pathway
GO:0071542 dopaminergic neuron differentiation
GO:0072659 protein localization to plasma membrane
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090103 cochlea morphogenesis
GO:0097178 ruffle assembly
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902622 regulation of neutrophil migration
GO:1904948 midbrain dopaminergic neuron differentiation
GO:2000386 positive regulation of ovarian follicle development

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Melanosome

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR003578 Small GTPase RhoFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
RAC1_MOUSERAD_MOUSEIntAct15102471 details
RAC1_MOUSECDC42_MOUSEBioGRID, IntAct15102471 32325033 details
RAC1_MOUSERHOA_MOUSEBioGRID, IntAct15102471 32325033 details
RAC1_MOUSENONO_MOUSEIntAct15102471 details
RAC1_MOUSEE41L2_MOUSEIntAct15102471 details
RAC1_MOUSEEVI5_MOUSEIntAct15102471 details
RAC1_MOUSELTBP1_MOUSEIntAct15102471 details
RAC1_MOUSERBM39_MOUSEBioGRID, IntAct15102471 32325033 details
RAC1_MOUSEPK3CB_MOUSEIntAct23706742 details
RAC1_MOUSERHG32_MOUSEBioGRID12531901 32325033 details
RAC1_MOUSERHG01_MOUSEBioGRID14966113 32325033 details
RAC1_MOUSERHG22_MOUSEBioGRID14966113 details
RAC1_MOUSERCC2_HUMANBioGRID25074804 details
RAC1_MOUSEAGAP2_HUMANBioGRID22453919 details
RAC1_MOUSETRAF6_MOUSEBioGRID29114077 details
RAC1_MOUSEUBC_MOUSEBioGRID29676259 details
RAC1_MOUSENMDE2_MOUSEBioGRID, IntAct10862698 16635246 details
RAC1_MOUSEPAK1_MOUSEMINT12123608 details
RAC1_MOUSECAV1_MOUSEMINT17658519 details
RAC1_MOUSEPAK1_HUMANIntAct, MINT18325335 18854161 19893577 details
RAC1_MOUSECHIO_MOUSEMINT19306875 details
RAC1_MOUSEDLG4_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
RAC1_MOUSESMUF2_MOUSEBioGRID, IntAct19379695 details
RAC1_MOUSEXIAP_MOUSEMINT22117219 details
RAC1_MOUSEGDIR1_HUMANMINT22157745 details
RAC1_MOUSESODC_MOUSEBioGRID, UniProt18219391 32325033 details
RAC1_MOUSETIAM1_MOUSEDIP16801538 details
RAC1_MOUSEHACD3_HUMANBioGRID10747961 details
RAC1_MOUSEHOME2_MOUSEBioGRID10493740 details
RAC1_MOUSECTRO_MOUSEBioGRID10493740 details
RAC1_MOUSEAKIP1_MOUSEBioGRID17227220 details
RAC1_MOUSEABR_MOUSEBioGRID17116687 details
RAC1_MOUSEBCR_MOUSEBioGRID17116687 details
RAC1_MOUSERCC2_MOUSEBioGRID25074804 32325033 details
RAC1_MOUSEGDIR1_MOUSEBioGRID25074804 details
RAC1_MOUSEDOCK1_MOUSEBioGRID21289086 details
RAC1_MOUSESGMR1_MOUSEBioGRID31149635 details
RAC1_MOUSEMAVS_MOUSEBioGRID31149635 details
RAC1_MOUSETRADD_MOUSEBioGRID31149635 details
RAC1_MOUSELRRK2_MOUSEBioGRID25926623 details