Entity Details

Primary name PRRX1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP63013
EntryNamePRRX1_MOUSE
FullNamePaired mesoderm homeobox protein 1
TaxID10090
Evidenceevidence at protein level
Length245
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesPrrx1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030326 embryonic limb morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048664 neuron fate determination
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048844 artery morphogenesis
GO:0051216 cartilage development
GO:0060021 roof of mouth development
GO:0070570 regulation of neuron projection regeneration
GO:0071837 HMG box domain binding
GO:0097150 neuronal stem cell population maintenance
GO:0100026 positive regulation of DNA repair by transcription from RNA polymerase II promoter

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR003654 OAR domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR043378 Paired mesoderm homeobox protein 1/2FamilyFamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
PRRX1_MOUSERBL2_HUMANIntAct9464541 details
PRRX1_MOUSEALX4_MOUSEBioGRID, IntAct20211142 details
PRRX1_MOUSESOX8_MOUSEBioGRID16582099 details