Entity Details

Primary name PAX6_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP63015
EntryNamePAX6_MOUSE
FullNamePaired box protein Pax-6
TaxID10090
Evidenceevidence at protein level
Length422
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesPax6

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000132 establishment of mitotic spindle orientation
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0001709 cell fate determination
GO:0001755 neural crest cell migration
GO:0001764 neuron migration
GO:0001933 negative regulation of protein phosphorylation
GO:0002052 positive regulation of neuroblast proliferation
GO:0002064 epithelial cell development
GO:0002088 lens development in camera-type eye
GO:0003002 regionalization
GO:0003309 type B pancreatic cell differentiation
GO:0003310 pancreatic A cell differentiation
GO:0003322 pancreatic A cell development
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007224 smoothened signaling pathway
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007435 salivary gland morphogenesis
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0009786 regulation of asymmetric cell division
GO:0009950 dorsal/ventral axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0010975 regulation of neuron projection development
GO:0019901 protein kinase binding
GO:0021517 ventral spinal cord development
GO:0021543 pallium development
GO:0021593 rhombomere morphogenesis
GO:0021772 olfactory bulb development
GO:0021778 oligodendrocyte cell fate specification
GO:0021796 cerebral cortex regionalization
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021902 commitment of neuronal cell to specific neuron type in forebrain
GO:0021905 forebrain-midbrain boundary formation
GO:0021978 telencephalon regionalization
GO:0021983 pituitary gland development
GO:0021986 habenula development
GO:0022027 interkinetic nuclear migration
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030334 regulation of cell migration
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031625 ubiquitin protein ligase binding
GO:0032808 lacrimal gland development
GO:0033365 protein localization to organelle
GO:0035035 histone acetyltransferase binding
GO:0042462 eye photoreceptor cell development
GO:0042593 glucose homeostasis
GO:0042660 positive regulation of cell fate specification
GO:0043010 camera-type eye development
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045664 regulation of neuron differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048505 regulation of timing of cell differentiation
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048708 astrocyte differentiation
GO:0048856 anatomical structure development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0060041 retina development in camera-type eye
GO:0061034 olfactory bulb mitral cell layer development
GO:0061072 iris morphogenesis
GO:0061303 cornea development in camera-type eye
GO:0061351 neural precursor cell proliferation
GO:0070094 positive regulation of glucagon secretion
GO:0070410 co-SMAD binding
GO:0070412 R-SMAD binding
GO:0071837 HMG box domain binding
GO:0098598 learned vocalization behavior or vocal learning
GO:0120008 positive regulation of glutamatergic neuron differentiation
GO:1901142 insulin metabolic process
GO:1904798 positive regulation of core promoter binding
GO:1904937 sensory neuron migration
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2001224 positive regulation of neuron migration

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR001523 Paired domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR043182 Paired DNA-binding domainDomainDomain
IPR043565 PAX familyFamilyFamily

Diseases

Show/Hide Table