Entity Details

Primary name HSP7C_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP63017
EntryNameHSP7C_MOUSE
FullNameHeat shock cognate 71 kDa protein
TaxID10090
Evidenceevidence at protein level
Length646
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesHspa8

GO terms

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GOName
GO:0000974 Prp19 complex
GO:0001664 G protein-coupled receptor binding
GO:0001786 phosphatidylserine binding
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001917 photoreceptor inner segment
GO:0003723 RNA binding
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0006606 protein import into nucleus
GO:0008021 synaptic vesicle
GO:0008134 transcription factor binding
GO:0008380 RNA splicing
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014069 postsynaptic density
GO:0016192 vesicle-mediated transport
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0030674 protein-macromolecule adaptor activity
GO:0031072 heat shock protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031686 A1 adenosine receptor binding
GO:0031906 late endosome lumen
GO:0032279 asymmetric synapse
GO:0032991 protein-containing complex
GO:0034620 cellular response to unfolded protein
GO:0042026 protein refolding
GO:0042277 peptide binding
GO:0042470 melanosome
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043085 positive regulation of catalytic activity
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043209 myelin sheath
GO:0043531 ADP binding
GO:0043624 cellular protein complex disassembly
GO:0044183 protein folding chaperone
GO:0044309 neuron spine
GO:0044788 modulation by host of viral process
GO:0044829 positive regulation by host of viral genome replication
GO:0045121 membrane raft
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046034 ATP metabolic process
GO:0046777 protein autophosphorylation
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0048471 perinuclear region of cytoplasm
GO:0050766 positive regulation of phagocytosis
GO:0051082 unfolded protein binding
GO:0051085 chaperone cofactor-dependent protein refolding
GO:0051087 chaperone binding
GO:0051726 regulation of cell cycle
GO:0051787 misfolded protein binding
GO:0055131 C3HC4-type RING finger domain binding
GO:0061077 chaperone-mediated protein folding
GO:0061635 regulation of protein complex stability
GO:0061684 chaperone-mediated autophagy
GO:0061738 late endosomal microautophagy
GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy
GO:0061741 obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy
GO:0070062 extracellular exosome
GO:0072318 clathrin coat disassembly
GO:0097214 positive regulation of lysosomal membrane permeability
GO:0098684 photoreceptor ribbon synapse
GO:0098690 glycinergic synapse
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098880 maintenance of postsynaptic specialization structure
GO:0098978 glutamatergic synapse
GO:0099175 regulation of postsynapse organization
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol
GO:0099634 postsynaptic specialization membrane
GO:0101031 chaperone complex
GO:1902904 negative regulation of supramolecular fiber organization
GO:1904592 positive regulation of protein refolding
GO:1904593 prostaglandin binding
GO:1904764 chaperone-mediated autophagy translocation complex disassembly
GO:1990124 messenger ribonucleoprotein complex
GO:1990832 slow axonal transport
GO:1990833 clathrin-uncoating ATPase activity
GO:1990836 lysosomal matrix
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Melanosome
Nucleus

Domains

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DomainNameCategoryType
IPR013126 Heat shock protein 70 familyFamilyFamily
IPR018181 Heat shock protein 70, conserved siteSiteConserved site
IPR029047 Heat shock protein 70kD, peptide-binding domain superfamilyFamilyHomologous superfamily
IPR029048 Heat shock protein 70kD, C-terminal domain superfamilyFamilyHomologous superfamily
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
HSP7C_MOUSEKLC1_MOUSEMINT20111006 details
HSP7C_MOUSEMTR1A_HUMANBioGRID, IntAct26514267 details
HSP7C_MOUSESNP25_MOUSEBioGRID21151134 details
HSP7C_MOUSEHSP7C_MOUSEBioGRID21151134 details
HSP7C_MOUSEDNJC5_MOUSEBioGRID21151134 details
HSP7C_MOUSESGTA_MOUSEBioGRID21151134 32325033 details
HSP7C_MOUSEMEF2D_MOUSEBioGRID19119233 details
HSP7C_MOUSEPLIN3_MOUSEDIP25961502 details
HSP7C_MOUSEPLIN2_MOUSEDIP25961502 details
HSP7C_MOUSEG3P_MOUSEBioGRID, DIP25961502 32325033 details
HSP7C_MOUSEIKBA_MOUSEDIP25961502 details
HSP7C_MOUSETAU_MOUSEBioGRID17954934 18346207 32325033 details
HSP7C_MOUSETRAF6_MOUSEBioGRID16196101 details
HSP7C_MOUSEKDM2B_MOUSEBioGRID17296600 32325033 details
HSP7C_MOUSEERG_MOUSEBioGRID21183741 details
HSP7C_MOUSEZFN2A_MOUSEBioGRID16973439 details
HSP7C_MOUSENMDZ1_MOUSEBioGRID10862698 details
HSP7C_MOUSEATX3_MOUSEBioGRID15639784 details
HSP7C_MOUSEBAG3_MOUSEBioGRID20884878 32325033 details
HSP7C_MOUSEFBX32_MOUSEBioGRID22673621 details
HSP7C_MOUSECHIP_MOUSEBioGRID23612611 32325033 details
HSP7C_MOUSECCND1_MOUSEBioGRID12588994 details
HSP7C_MOUSECDN1A_MOUSEBioGRID12588994 details
HSP7C_MOUSECDK4_MOUSEBioGRID12588994 details
HSP7C_MOUSECIDEC_MOUSEBioGRID25315694 details
HSP7C_MOUSEKAT5_MOUSEBioGRID24302573 details
HSP7C_MOUSEM3K14_MOUSEBioGRID25792747 details
HSP7C_MOUSEKCNA5_MOUSEBioGRID26232501 details
HSP7C_MOUSEINADL_MOUSEBioGRID19138174 details
HSP7C_MOUSECHIP_HUMANBioGRID29091030 details
HSP7C_MOUSEH31_HUMANBioGRID25330109 details
HSP7C_MOUSENEB2_MOUSEBioGRID28634551 30562941 details