Entity Details

Primary name MK01_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP63085
EntryNameMK01_MOUSE
FullNameMitogen-activated protein kinase 1
TaxID10090
Evidenceevidence at protein level
Length358
SequenceStatuscomplete
DateCreated2004-09-13
DateModified2021-06-02

Ontological Relatives

GenesMapk1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001784 phosphotyrosine residue binding
GO:0003690 double-stranded DNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007507 heart development
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0014032 neural crest cell development
GO:0014069 postsynaptic density
GO:0015966 diadenosine tetraphosphate biosynthetic process
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019233 sensory perception of pain
GO:0019858 cytosine metabolic process
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030278 regulation of ossification
GO:0030424 axon
GO:0030641 regulation of cellular pH
GO:0030878 thyroid gland development
GO:0031143 pseudopodium
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031647 regulation of protein stability
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032496 response to lipopolysaccharide
GO:0032839 dendrite cytoplasm
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032991 protein-containing complex
GO:0033598 mammary gland epithelial cell proliferation
GO:0034198 cellular response to amino acid starvation
GO:0034614 cellular response to reactive oxygen species
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0038127 ERBB signaling pathway
GO:0042307 positive regulation of protein import into nucleus
GO:0042473 outer ear morphogenesis
GO:0042802 identical protein binding
GO:0043204 perikaryon
GO:0043330 response to exogenous dsRNA
GO:0043627 response to estrogen
GO:0045596 negative regulation of cell differentiation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046697 decidualization
GO:0048538 thymus development
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051493 regulation of cytoskeleton organization
GO:0051973 positive regulation of telomerase activity
GO:0060020 Bergmann glial cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060291 long-term synaptic potentiation
GO:0060324 face development
GO:0060425 lung morphogenesis
GO:0060440 trachea formation
GO:0060716 labyrinthine layer blood vessel development
GO:0061308 cardiac neural crest cell development involved in heart development
GO:0070371 ERK1 and ERK2 cascade
GO:0070849 response to epidermal growth factor
GO:0071276 cellular response to cadmium ion
GO:0071310 cellular response to organic substance
GO:0071356 cellular response to tumor necrosis factor
GO:0072584 caveolin-mediated endocytosis
GO:0072686 mitotic spindle
GO:0090170 regulation of Golgi inheritance
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120041 positive regulation of macrophage proliferation
GO:1903351 cellular response to dopamine
GO:1904355 positive regulation of telomere capping
GO:2000641 regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2FamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
MK01_MOUSEATF2_MOUSEBioGRID, MINT15192015 15304344 details
MK01_MOUSEMKNK2_MOUSEIntAct15102471 details
MK01_MOUSEMKNK1_MOUSEIntAct15102471 details
MK01_MOUSERHDF2_MOUSEIntAct15102471 details
MK01_MOUSEZMY11_MOUSEIntAct15102471 details
MK01_MOUSEZEP1_MOUSEIntAct15102471 details
MK01_MOUSEKS6A4_MOUSEIntAct15102471 details
MK01_MOUSENUP58_MOUSEIntAct15102471 details
MK01_MOUSECP135_MOUSEIntAct15102471 details
MK01_MOUSECROCC_MOUSEIntAct15102471 details
MK01_MOUSEB2L11_HUMANIntAct16282323 details
MK01_MOUSEELK1_HUMANIntAct16533805 details
MK01_MOUSEGSK3B_HUMANIntAct18045539 details
MK01_MOUSESQSTM_MOUSEBioGRID, MINT16517408 20154642 details
MK01_MOUSEDUS6_MOUSEMINT16148006 details
MK01_MOUSEPTPRR_MOUSEMINT10419510 16148006 details
MK01_MOUSEDUS9_HUMANMINT11988087 details
MK01_MOUSEDJC27_MOUSEIntAct24746703 details
MK01_MOUSEMP2K1_HUMANHPIDb20554783 details
MK01_MOUSECEBPB_MOUSEDIP17264204 details
MK01_MOUSEKLF4_MOUSEDIP22307056 details
MK01_MOUSESNAI1_HUMANDIP23644467 details
MK01_MOUSEKLF11_HUMANBioGRID12006497 details
MK01_MOUSEP53_HUMANBioGRID10958792 details
MK01_MOUSEPEA15_MOUSEBioGRID15537391 32325033 details
MK01_MOUSEELK1_MOUSEBioGRID11435472 15767678 9687507 details
MK01_MOUSEITB5_MOUSEBioGRID11857080 details
MK01_MOUSEDUS2_MOUSEBioGRID16288922 details
MK01_MOUSE4EBP1_MOUSEBioGRID8939971 details
MK01_MOUSE4EBP2_MOUSEBioGRID8939971 details
MK01_MOUSEMBP_MOUSEBioGRID10362356 15544353 details
MK01_MOUSEPAXI_MOUSEBioGRID14636584 details
MK01_MOUSEB2CL1_HUMANBioGRID16282323 details
MK01_MOUSENANOG_MOUSEBioGRID24793005 details
MK01_MOUSEKS6A3_MOUSEBioGRID24793005 details
MK01_MOUSEMP2K1_MOUSEBioGRID11435472 21144847 32325033 details
MK01_MOUSEPTN5_HUMANBioGRID25583483 details
MK01_MOUSETNR1A_MOUSEBioGRID15865443 details
MK01_MOUSEITA2B_MOUSEBioGRID30333137 details
MK01_MOUSENR4A2_HUMANBioGRID17681692 details
MK01_MOUSENMDE2_MOUSEBioGRID, IntAct10862698 16635246 details
MK01_MOUSEDLG4_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
MK01_MOUSEMK01_MOUSEIntAct26267534 details
MK01_MOUSEEFNB3_MOUSEDIP20410461 details
MK01_MOUSEPER1_MOUSEDIP21179498 details
MK01_MOUSECRY1_MOUSEDIP21179498 details
MK01_MOUSEPER2_MOUSEDIP21179498 details
MK01_MOUSECRY2_MOUSEDIP21179498 details
MK01_MOUSETOP2A_MOUSEBioGRID10207078 details
MK01_MOUSEPCY1A_MOUSEBioGRID19332566 details
MK01_MOUSEBLNK_MOUSEBioGRID15087455 details
MK01_MOUSESRC8_MOUSEBioGRID22514278 details
MK01_MOUSEVRK3_MOUSEBioGRID18035061 details
MK01_MOUSEDUS3_MOUSEBioGRID18035061 32325033 details
MK01_MOUSECAN2_MOUSEBioGRID14993287 32325033 details
MK01_MOUSEMAP2_MOUSEBioGRID15544353 details
MK01_MOUSEFER_MOUSEBioGRID15567065 details
MK01_MOUSEKSR1_MOUSEBioGRID19114553 details
MK01_MOUSEJIP3_MOUSEBioGRID21156008 details