Entity Details

Primary name GBRB2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP63137
EntryNameGBRB2_MOUSE
FullNameGamma-aminobutyric acid receptor subunit beta-2
TaxID10090
Evidenceevidence at protein level
Length512
SequenceStatuscomplete
DateCreated2004-09-13
DateModified2021-06-02

Ontological Relatives

GenesGabrb2

GO terms

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GOName
GO:0004890 GABA-A receptor activity
GO:0005237 inhibitory extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007605 sensory perception of sound
GO:0016020 membrane
GO:0022851 GABA-gated chloride ion channel activity
GO:0030594 neurotransmitter receptor activity
GO:0031410 cytoplasmic vesicle
GO:0034220 ion transmembrane transport
GO:0034707 chloride channel complex
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045202 synapse
GO:0048666 neuron development
GO:0050877 nervous system process
GO:0051932 synaptic transmission, GABAergic
GO:0060119 inner ear receptor cell development
GO:0060384 innervation
GO:0071420 cellular response to histamine
GO:0090102 cochlea development
GO:0098982 GABA-ergic synapse
GO:0099060 integral component of postsynaptic specialization membrane
GO:1901215 negative regulation of neuron death
GO:1902476 chloride transmembrane transport
GO:1902710 GABA receptor complex
GO:1902711 GABA-A receptor complex
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:1904862 inhibitory synapse assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR002289 Gamma-aminobutyric-acid A receptor, beta subunitFamilyFamily
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alphaFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions