Entity Details

Primary name TRAF6_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70196
EntryNameTRAF6_MOUSE
FullNameTNF receptor-associated factor 6
TaxID10090
Evidenceevidence at protein level
Length530
SequenceStatuscomplete
DateCreated2003-05-09
DateModified2021-06-02

Ontological Relatives

GenesTraf6

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0001503 ossification
GO:0001701 in utero embryonic development
GO:0001843 neural tube closure
GO:0002637 regulation of immunoglobulin production
GO:0002726 positive regulation of T cell cytokine production
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006955 immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007254 JNK cascade
GO:0008270 zinc ion binding
GO:0009887 animal organ morphogenesis
GO:0009898 cytoplasmic side of plasma membrane
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0030316 osteoclast differentiation
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0031996 thioesterase binding
GO:0032147 activation of protein kinase activity
GO:0032735 positive regulation of interleukin-12 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035631 CD40 receptor complex
GO:0042088 T-helper 1 type immune response
GO:0042102 positive regulation of T cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0042981 regulation of apoptotic process
GO:0043011 myeloid dendritic cell differentiation
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043422 protein kinase B binding
GO:0043507 positive regulation of JUN kinase activity
GO:0045453 bone resorption
GO:0045672 positive regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046849 bone remodeling
GO:0047485 protein N-terminus binding
GO:0048468 cell development
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070534 protein K63-linked ubiquitination
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071345 cellular response to cytokine stimulus
GO:0097400 interleukin-17-mediated signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:2000679 positive regulation of transcription regulatory region DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Lipid droplet
Nucleus

Domains

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DomainNameCategoryType
IPR001293 Zinc finger, TRAF-typeDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR002083 MATH/TRAF domainDomainDomain
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR012227 TNF receptor-associated factor TRAF, metazoaFamilyFamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027139 TNF receptor-associated factor 6FamilyFamily
IPR037309 TNF receptor-associated factor 6, MATH domainDomainDomain
IPR041310 TNF receptor-associated factor 6, zinc finger 2DomainDomain
IPR043211 TNF receptor-associated factor TRAFFamilyFamily

Diseases

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Interactions

115 interactions

InteractorPartnerSourcesPublicationsLink
TRAF6_MOUSETIFA_MOUSEBioGRID, IntAct12566447 details
TRAF6_MOUSEIRAK1_MOUSEBioGRID, IntAct12566447 15102471 16831874 21460221 details
TRAF6_MOUSETNR5_MOUSEBioGRID, IntAct10748240 18635759 8910514 details
TRAF6_MOUSEECSIT_MOUSEBioGRID, DIP, IntAct10465784 15102471 21525932 details
TRAF6_MOUSECIKS_MOUSEBioGRID, InnateDB, IntAct15102471 21822257 22649194 details
TRAF6_MOUSEBAG6_MOUSEBioGRID, IntAct15102471 27501752 details
TRAF6_MOUSEFHL1_MOUSEIntAct15102471 details
TRAF6_MOUSEPAXI_MOUSEIntAct15102471 details
TRAF6_MOUSECALR_MOUSEIntAct15102471 details
TRAF6_MOUSECK053_MOUSEIntAct15102471 details
TRAF6_MOUSEIRAK3_MOUSEBioGRID, IntAct, MINT15102471 21098228 23376919 details
TRAF6_MOUSETRAD1_MOUSEBioGRID, UniProt16221674 details
TRAF6_MOUSEUBE2N_MOUSEBioGRID, InnateDB19136968 20185725 21765415 details
TRAF6_MOUSEIRF7_MOUSEBioGRID, InnateDB21743479 23042151 details
TRAF6_MOUSETNR11_MOUSEBioGRID, IntAct10097072 11406619 14500659 details
TRAF6_MOUSEMYD88_MOUSEBioGRID, DIP16306937 19898473 22011580 30108181 31268348 details
TRAF6_MOUSENEMO_MOUSEBioGRID, DIP18216269 19136968 21566132 26474655 details
TRAF6_MOUSETRAF6_MOUSEBioGRID, DIP15147900 17709375 19465916 28993672 details
TRAF6_MOUSEM3K14_HUMANBioGRID11278268 details
TRAF6_MOUSESRA1_MOUSEBioGRID21460221 details
TRAF6_MOUSETCAM1_MOUSEBioGRID14530355 19898473 details
TRAF6_MOUSEUBE2N_HUMANBioGRID15147900 17709375 28993672 details
TRAF6_MOUSEARRB1_MOUSEBioGRID16378096 details
TRAF6_MOUSEARRB2_MOUSEBioGRID16378096 23960234 details
TRAF6_MOUSEUB2V1_HUMANBioGRID17709375 details
TRAF6_MOUSEUB2D3_HUMANBioGRID17709375 details
TRAF6_MOUSEITB1_MOUSEBioGRID25808491 details
TRAF6_MOUSEMYSM1_MOUSEBioGRID26474655 details
TRAF6_MOUSERAC1_MOUSEBioGRID29114077 details
TRAF6_MOUSEKS6A3_MOUSEBioGRID29563609 details
TRAF6_MOUSEM3K3_MOUSEIntAct, MINT14661019 16362041 details
TRAF6_MOUSEHS71B_MOUSEBioGRID, MINT16697380 details
TRAF6_MOUSETRAD1_HUMANUniProt16221674 details
TRAF6_MOUSEUBB_MOUSEDIP, IntAct, MINT18083102 19091944 19131965 19815506 26649818 details
TRAF6_MOUSEUBC_MOUSEDIP, IntAct, MINT18083102 19091944 19131965 19815506 26649818 details
TRAF6_MOUSERS27A_MOUSEDIP, IntAct, MINT18083102 19091944 19131965 19815506 26649818 details
TRAF6_MOUSERL40_MOUSEDIP, IntAct, MINT18083102 19091944 19131965 19815506 26649818 details
TRAF6_MOUSENR0B2_MOUSEBioGRID, InnateDB14500659 21725320 details
TRAF6_MOUSENR0B2_HUMANInnateDB21725320 details
TRAF6_MOUSEITCH_MOUSEBioGRID, InnateDB18246070 20185725 21765415 23782702 details
TRAF6_MOUSERNF11_MOUSEBioGRID, InnateDB20185725 21765415 details
TRAF6_MOUSETNAP3_MOUSEBioGRID, InnateDB17703191 20185725 21765415 details
TRAF6_MOUSEM3K7_MOUSEBioGRID, InnateDB18635759 19898473 22057290 22637723 22649194 23960234 24558484 25828701 26474655 details
TRAF6_MOUSEPTN11_MOUSEInnateDB22522491 details
TRAF6_MOUSENLRC3_HUMANInnateDB22863753 details
TRAF6_MOUSEPTN6_MOUSEInnateDB23001144 details
TRAF6_MOUSEUBP25_MOUSEInnateDB23042150 details
TRAF6_MOUSEERN1_MOUSEMINT23942232 details
TRAF6_MOUSETIFA_HUMANUniProt15047173 details
TRAF6_MOUSETNR27_MOUSEBioGRID12060722 details
TRAF6_MOUSETNR19_MOUSEBioGRID12060722 details
TRAF6_MOUSECYLD_MOUSEBioGRID18174161 18382763 23782702 details
TRAF6_MOUSEMALT1_MOUSEBioGRID16831874 details
TRAF6_MOUSEACTN4_MOUSEBioGRID16196101 details
TRAF6_MOUSEACTN1_MOUSEBioGRID16196101 details
TRAF6_MOUSEWDR24_MOUSEBioGRID16196101 details
TRAF6_MOUSEEF2_MOUSEBioGRID16196101 details
TRAF6_MOUSEHS90B_MOUSEBioGRID16196101 details
TRAF6_MOUSEHS90A_MOUSEBioGRID16196101 details
TRAF6_MOUSEBIP_MOUSEBioGRID16196101 details
TRAF6_MOUSEGRP75_MOUSEBioGRID16196101 details
TRAF6_MOUSEVATA_MOUSEBioGRID16196101 details
TRAF6_MOUSEHSP7C_MOUSEBioGRID16196101 details
TRAF6_MOUSEHSP72_MOUSEBioGRID16196101 details
TRAF6_MOUSEKPYM_MOUSEBioGRID16196101 details
TRAF6_MOUSEATPB_MOUSEBioGRID16196101 details
TRAF6_MOUSEEF1A1_MOUSEBioGRID16196101 details
TRAF6_MOUSEARP3_MOUSEBioGRID16196101 details
TRAF6_MOUSEENOA_MOUSEBioGRID16196101 details
TRAF6_MOUSEACTB_MOUSEBioGRID16196101 details
TRAF6_MOUSEALDOA_MOUSEBioGRID16196101 details
TRAF6_MOUSEUB2D3_MOUSEBioGRID20185725 21765415 details
TRAF6_MOUSETAXB1_MOUSEBioGRID18239685 20185725 21765415 details
TRAF6_MOUSETLR4_MOUSEBioGRID19898473 23962979 details
TRAF6_MOUSERSAD2_MOUSEBioGRID21435586 details
TRAF6_MOUSENLRX1_MOUSEBioGRID21703539 details
TRAF6_MOUSENRIF1_MOUSEBioGRID16252010 details
TRAF6_MOUSECBL_MOUSEBioGRID11406619 details
TRAF6_MOUSERIPK1_MOUSEBioGRID18246070 details
TRAF6_MOUSERNF41_MOUSEBioGRID19483718 details
TRAF6_MOUSEIRF5_MOUSEBioGRID18824541 details
TRAF6_MOUSEFHL2_MOUSEBioGRID16184196 details
TRAF6_MOUSETR13C_MOUSEBioGRID21041452 details
TRAF6_MOUSEI17RA_MOUSEBioGRID10748240 details
TRAF6_MOUSERIPK2_MOUSEBioGRID17947236 details
TRAF6_MOUSEI17RB_MOUSEBioGRID23355738 details
TRAF6_MOUSETNR16_MOUSEBioGRID22503986 details
TRAF6_MOUSESQSTM_MOUSEBioGRID17389358 details
TRAF6_MOUSEWWP1_MOUSEBioGRID23799152 details
TRAF6_MOUSEMAVS_MOUSEBioGRID23951545 details
TRAF6_MOUSEAKT1_MOUSEBioGRID23907468 25808491 details
TRAF6_MOUSEPR15A_MOUSEBioGRID23907468 details
TRAF6_MOUSEMTOR_MOUSEBioGRID23911927 details
TRAF6_MOUSEKSYK_MOUSEBioGRID23962979 details
TRAF6_MOUSECHIP_MOUSEBioGRID24578159 details
TRAF6_MOUSEPKHO1_MOUSEBioGRID24777252 details
TRAF6_MOUSELIMD1_MOUSEBioGRID17092936 details
TRAF6_MOUSEIRF4_MOUSEBioGRID24670424 details
TRAF6_MOUSESTK26_MOUSEBioGRID25642822 details
TRAF6_MOUSETRAF3_MOUSEBioGRID26474655 details
TRAF6_MOUSETAB2_MOUSEBioGRID25828701 26474655 details
TRAF6_MOUSETAB3_MOUSEBioGRID26474655 details
TRAF6_MOUSEDOK3_MOUSEBioGRID26548852 details
TRAF6_MOUSETLR3_MOUSEBioGRID25828701 details
TRAF6_MOUSEGSK3B_MOUSEBioGRID25828701 details
TRAF6_MOUSETAB1_MOUSEBioGRID25828701 details
TRAF6_MOUSETCAM2_MOUSEBioGRID25828701 details
TRAF6_MOUSEBID_MOUSEBioGRID27257617 details
TRAF6_MOUSESMN_MOUSEBioGRID28214532 details
TRAF6_MOUSEVAV3_MOUSEBioGRID27507811 details
TRAF6_MOUSECR3L3_MOUSEBioGRID27637329 details
TRAF6_MOUSECUL5_MOUSEBioGRID27233966 details
TRAF6_MOUSEMABP1_MOUSEBioGRID19385034 details
TRAF6_MOUSEZC12A_MOUSEBioGRID29975947 details
TRAF6_MOUSERXRA_MOUSEBioGRID30931933 details